Reversal of abnormalities of myelination by thyroxine therapy in congenital hypothyroidism: localized in vivo proton magnetic resonance spectroscopy (MRS) study

Deficiency of thyroid hormone during central nervous system ontogeny results in a variety of clinical, anatomical and biochemical defects. Delay in thyroxine therapy in newborns with congenital hypothyroidism leads to irreversible brain damage. We have used localized in vivo proton magnetic resonanc...

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Bibliographic Details
Published in:Brain research. Developmental brain research 1998-08, Vol.109 (2), p.179-186
Main Authors: Jagannathan, N.R, Tandon, N, Raghunathan, P, Kochupillai, N
Format: Article
Language:English
Subjects:
Adolescent
Adult
Brain - pathology
Brain Chemistry - physiology
Central nervous system ontogeny
Child
Congenital Hypothyroidism
Demyelinating Diseases - drug therapy
Demyelinating Diseases - etiology
Demyelinating Diseases - pathology
Female
Humans
Hypothyroidism - complications
Hypothyroidism - pathology
Magnetic Resonance Spectroscopy
Male
Myelination
Proton magnetic resonance spectroscopy
Reference Values
Thyroxine
Thyroxine - therapeutic use
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Summary:Deficiency of thyroid hormone during central nervous system ontogeny results in a variety of clinical, anatomical and biochemical defects. Delay in thyroxine therapy in newborns with congenital hypothyroidism leads to irreversible brain damage. We have used localized in vivo proton magnetic resonance spectroscopy (MRS) to assess biochemical changes in different regions of brain in three patients with congenital hypothyroidism before and after thyroxine therapy. An abnormal lipid peak which disappeared with thyroxine therapy was observed in cerebellum and frontal lobe in one patient. Statistically significant reduction of NAA/(Cr+PCr) [ P
ISSN:0165-3806
DOI:10.1016/S0165-3806(98)00081-9