Latexin expression in smaller diameter primary sensory neurons in the rat

Most of the smaller diameter neurons of dorsal root and trigeminal ganglia in adult rats expressed latexin, which has the inhibitor activity of carboxypeptidase A. Most of the dorsal root ganglion (DRG) neurons containing either calcitonin gene-related peptide (CGRP), substance P (SP) or somatostati...

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Bibliographic Details
Published in:Brain research 1998-08, Vol.801 (1), p.9-20
Main Authors: Takiguchi-Hayashi, Keiko, Sato, Michio, Sugo, Noriyuki, Ishida, Mami, Sato, Kazuki, Uratani, Yoshihiko, Arimatsu, Yasuyoshi
Format: Article
Language:English
Subjects:
Animals
Antigens - analysis
Antigens - biosynthesis
Biological and medical sciences
Blotting, Western
Capsaicin - pharmacology
Cells, Cultured
Dorsal root ganglion
Fundamental and applied biological sciences. Psychology
Ganglia, Spinal - chemistry
Ganglia, Spinal - cytology
Ganglia, Spinal - drug effects
Immunohistochemistry
Microscopy, Immunoelectron
Nerve Tissue Proteins
Neurons, Afferent - chemistry
Neurons, Afferent - cytology
Neurons, Afferent - ultrastructure
Nociceptors - chemistry
Nociceptors - cytology
Pain
Rats
Rats, Wistar
Somesthesis and somesthetic pathways (proprioception, exteroception, nociception)
interoception
electrolocation. Sensory receptors
Spinal cord
Spinal Cord - cytology
Spinal Cord - ultrastructure
Trigeminal ganglion
Vertebrates: nervous system and sense organs
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Summary:Most of the smaller diameter neurons of dorsal root and trigeminal ganglia in adult rats expressed latexin, which has the inhibitor activity of carboxypeptidase A. Most of the dorsal root ganglion (DRG) neurons containing either calcitonin gene-related peptide (CGRP), substance P (SP) or somatostatin (SST) coexpressed latexin. Latexin was widely distributed in the cytoplasm of the cell body and in axonal fibers of cultured DRG neurons which were sensitive to capsaicin. In addition, latexin-immunoreactivity was observed throughout lamina II of the spinal cord in normal animals, but was lost following sciatic nerve-axotomy, suggesting the presence of latexin-immunoreactive axonal fibers and/or terminals from DRG neurons. Immunoelectron microscopy indeed revealed latexin-immunoreactive axonal terminals and thinly myelinated and unmyelinated axonal fibers within the dorsal horn. These observations suggest that latexin may be involved in nociceptive information transmission or its modulation.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00496-X