Preparation and dissolution rate of gliquidone-PVP K30 solid dispersions

Solid dispersions of gliquidone in PVP K30 were prepared by the solvent method. These dispersions were characterized using X-ray diffraction. In comparison with the drug alone, the physical mixtures and even more the solid dispersions showed an increase in the dissolution rate. Moreover these solid...

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Bibliographic Details
Published in:European journal of drug metabolism and pharmacokinetics 1998-04, Vol.23 (2), p.113-117
Main Authors: MARTNEZ, P, GONI, M. M, CANTERA, R. G, MARTIN, C, DIOS-VIEITEZ, C, MARTINEZ-OHARRIZ, C
Format: Article
Language:English
Subjects:
Biological and medical sciences
Drug Stability
Drug Storage
Hormones. Endocrine system
Hypoglycemic Agents - chemistry
Medical sciences
Pharmacology. Drug treatments
Povidone - chemistry
Solubility
Sulfonylurea Compounds - chemistry
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Summary:Solid dispersions of gliquidone in PVP K30 were prepared by the solvent method. These dispersions were characterized using X-ray diffraction. In comparison with the drug alone, the physical mixtures and even more the solid dispersions showed an increase in the dissolution rate. Moreover these solid dispersions were stable during storage.
ISSN:0378-7966
2107-0180
DOI:10.1007/BF03189325