Effect of tylosin tartrate (Tylan Soluble) on cellular immune responses in chickens

Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin...

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Bibliographic Details
Published in:Poultry science 1998-09, Vol.77 (9), p.1306-1311
Main Authors: Baba, T. (Osaka Prefecture University, Sakai, Osaka, Japan.), Yamashita, N, Kodama, H, Murkamoto, M, Asada, M, Nakamoto, K, Nose, Y, McGruders, E.D
Format: Article
Language:English
Subjects:
Animals
Anti-Bacterial Agents - pharmacology
Bronchi - cytology
Cell Adhesion
CELL CULTURE
Cell Division - drug effects
CELL MEDIATED IMMUNITY
CELLS
CELLULE
CELULAS
Chemotaxis, Leukocyte
CHICKENS
Chickens - immunology
CITOQUINAS
CULTIVO DE CELULAS
CULTURE DE CELLULE
CULTURE MEDIA
Culture Media, Conditioned
CYTOKINE
CYTOKINES
IMMUNITE CELLULAIRE
Immunity, Cellular - drug effects
IMMUNOSTIMULATION NON SPECIFIQUE
INMUNIDAD CELULAR
INMUNOESTIMULACION NO ESPECIFICA
Killer Cells, Natural - immunology
LINFOCITOS
LYMPHOCYTE
Lymphocyte Activation - drug effects
LYMPHOCYTE TRANSFORMATION
LYMPHOCYTES
Lymphocytes - immunology
MEDIO DE CULTIVO
MILIEU DE CULTURE
Mitogens - pharmacology
NATURAL KILLER CELLS
NONSPECIFIC IMMUNOSTIMULATION
POLLO
POULET
Pulmonary Alveoli - cytology
Spleen - cytology
Spleen - immunology
SPLEEN CELLS
TILOSINA
TYLOSIN
Tylosin - pharmacology
TYLOSINE
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Summary:Although many antimicrobial agents have been reported to cause immunosuppression in animals, macrolide antibiotics enhance immune function. Tylosin is a macrolide antibiotic approved for the control of mycoplasmosis in poultry. The purpose of this investigation was to determine the effect of tylosin on cellular immune functions in chickens. There was no significant difference in adherent splenocyte chemotaxis between tylosin-treated and untreated (control) chickens. Tylosin increased splenocyte proliferation and splenocyte conditioned medium (CM) proliferative activity above control levels. Removal of adherent splenocytes before preparation of CM caused a reduction in CM proliferative activity. Tylosin also increased anti- tumor activity of splenocytes. These data are the first to suggest that the macrolide antibiotic, tylosin tartrate, has a modulatory effect in chickens on the immune parameters studied
ISSN:0032-5791
1525-3171
DOI:10.1093/ps/77.9.1306