Reduced number and altered morphology of microglial cells in colony stimulating factor-1-deficient osteopetrotic op/op mice

The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microg...

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Bibliographic Details
Published in:Brain research 1998-08, Vol.804 (1), p.135-139
Main Authors: Węgiel, Jerzy, Wiśniewski, Henryk M., Dziewiątkowski, Jerzy, Tarnawski, Michał, Kozielski, Rafał, Trenkner, Ekkhart, Wiktor-Jędrzejczak, Wiesław
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Brain - pathology
Cell Count
Corpus Callosum - pathology
Diseases of the osteoarticular system
Frontal Lobe - pathology
Growth factor
Immunohistochemistry
M-CSF
Macrophage
Macrophage Colony-Stimulating Factor - deficiency
Male
Malformations and congenital and or hereditary diseases involving bones. Joint deformations
Medical sciences
Mice
Mice, Inbred Strains - genetics
Microglia
Microglia - pathology
Mutation
Osteopetrosis - genetics
Osteopetrosis - metabolism
Osteopetrosis - pathology
Osteopetrotic op/op mouse
Parietal Lobe - pathology
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Summary:The numerical density of microglial cells is reduced by 47% in the corpus callosum, by 37% in the parietal cortex and by 34% in the frontal cortex of mice mutant at the op locus which are totally devoid of colony stimulating factor-1 (CSF-1), the major growth factor for macrophages. Moreover, microglia in the frontal cortex of the op/op mice are smaller and have shorter cytoplasmic processes compared to control mice. Study suggests that CSF-1 plays a role in vivo in the formation and maturation of microglia and has little or no effect on perivascular cells.
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00618-0