LABORATORY AND CLINICAL STUDIES ON CEFROXADINE IN PEDIATRIC FIELD

Cefroxadine (CGP-9000, CXD) is an orally active cephalosporin which has been newly developed by Ciba-Geigy. Its antibacterial activity against clinically isolated organisms, absorption and excretion after oral administration and clinical responses of patients with infections were studied. Its antiba...

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Bibliographic Details
Published in:Japanese journal of antibiotics 1981/12/25, Vol.34(12), pp.1655-1662
Main Authors: KAWAMURA, YOSHIAKI, NOMURA, TOYOKI, IHARA, TOSHIAKI, SHIMIZU, SHIN, KAMIYA, HITOSHI, SAKURAI, MINORU, NISHI, HIDEAKI
Format: Article
Language:Japanese
Subjects:
Adolescent
Bacteria - drug effects
Bacterial Infections - drug therapy
Bacterial Infections - microbiology
Cephalosporins - therapeutic use
Cephradine - analogs & derivatives
Cephradine - blood
Cephradine - pharmacology
Cephradine - therapeutic use
Child
Child, Preschool
Drug Evaluation
Drug Resistance, Microbial
Female
Humans
Infant
Male
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Summary:Cefroxadine (CGP-9000, CXD) is an orally active cephalosporin which has been newly developed by Ciba-Geigy. Its antibacterial activity against clinically isolated organisms, absorption and excretion after oral administration and clinical responses of patients with infections were studied. Its antibacterial activity against S. aureus and K. pneumoniae was comparable to that of CEX. Against E. coli, it showed slightly stronger activity than CEX. The serum concentrations of CXD was measured in 6 patients given orally 10mg/kg of it after meals. The peak mean serum level attained1hour after administration was 11.66mcg/ml. Forty-three children with various infections (upper respiratory infections, lower respiratory infections, urinary tract infections, etc.) were given 17-46mg/kg (average 28.7mg/kg) of CXD daily. The result was excellent in 26 cases, good in 12 cases, fair in 3 cases and poor in 2 cases, showing an effective rate of 88.4%. Side effect of transient leukopenia and elevation of S-GOT were noticed in 2 cases. However, there were no serious adversed reactions in our study. It is concluded that CXD might be effective in rather mild cases of respiratory or urinary tract infections.
ISSN:0368-2781
2186-5477
DOI:10.11553/antibiotics1968b.34.1655