Primary Culture of Cholangiocytes from Normal Mouse Liver

Cholangiocytes have been thought to play a role as antigen presenting cells or target cells in immune-mediated cholangitis. The aberrant expression of MHC class II proteins on cholangiocytes in primary biliary cirrhosis raises the possibility that cholangiocytes can function as antigen presenting ce...

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Bibliographic Details
Published in:In vitro cellular & developmental biology. Animal 1998-07, Vol.34 (7), p.512-514
Main Authors: Kaichiro Yahagi, Motoyasu Ishii, Koju Kobayashi, Ueno, Yoshiyuki, Yutaka Mano, Hirofumi Niitsuma, Takehiko Igarashi, Takayoshi Toyota
Format: Article
Language:English
Subjects:
Animals
Antigen presenting cells
Base Sequence
Cell Culture Techniques
Cultured cells
DNA Primers
Epithelial cells
Female
Fluorescent Antibody Technique
Gels
Hepatocytes
Histocompatibility Antigens Class II - genetics
Histocompatibility Antigens Class II - metabolism
Interferon-gamma - pharmacology
Letters to the Editor
Liver
Liver - cytology
Liver - drug effects
Liver - metabolism
Liver cells
Mice
Mice, Inbred BALB C
Molecules
Polymerase chain reaction
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Summary:Cholangiocytes have been thought to play a role as antigen presenting cells or target cells in immune-mediated cholangitis. The aberrant expression of MHC class II proteins on cholangiocytes in primary biliary cirrhosis raises the possibility that cholangiocytes can function as antigen presenting cells and, in immune-mediated cholangitis, cholangiocytes appeared to be targeted by lymphocytes (8). To explore the immune mechanisms underlying cholangitis, a culture of mouse cholangiocytes is essential, because the mouse is indispensable for immunological study.
ISSN:1071-2690
1543-706X
DOI:10.1007/s11626-998-0106-x