The effects of histamine H3-receptor antagonists on amygdaloid kindled seizures in rats

The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizure...

Full description

Saved in:
Bibliographic Details
Published in:Brain research bulletin 1998-07, Vol.46 (5), p.461-465
Main Authors: KAKINOKI, H, ISHIZAWA, K, FUKUNAGA, M, FUJII, Y, KAMEI, C
Format: Article
Language:English
Subjects:
Amygdala - physiology
Animals
Biological and medical sciences
Brain Chemistry - drug effects
Enzyme Inhibitors - pharmacology
Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy
Histamine Antagonists - pharmacology
Histamine N-Methyltransferase - antagonists & inhibitors
Imidazoles - administration & dosage
Imidazoles - pharmacology
Injections, Intraventricular
Kindling, Neurologic - physiology
Male
Medical sciences
Nervous system (semeiology, syndromes)
Neurology
Piperidines - administration & dosage
Piperidines - pharmacology
Pyrimethamine - analogs & derivatives
Pyrimethamine - pharmacology
Rats
Rats, Wistar
Receptors, Histamine H3 - metabolism
Seizures - physiopathology
Thiourea - administration & dosage
Thiourea - analogs & derivatives
Thiourea - pharmacology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The effects of histamine H3-receptor antagonists, thioperamide, and clobenpropit on amygdaloid kindled seizures were investigated in rats. Both intracerebroventricular (i.c.v.) and intraperitoneal (i.p.) injections of H3-antagonists resulted in a dose-related inhibition of amygdaloid kindled seizures. An inhibition induced by thioperamide was antagonized by an H3-agonist [(R)-alpha-methylhistamine] and H1-antagonists (diphenhydramine and chlorpheniramine). On the other hand, an H2-antagonist (cimetidine and ranitidine) caused no antagonistic effect. Metoprine, an inhibitor of N-methyltransferase was also effective in inhibiting amygdaloid kindled seizure, and this effect was augmented by thioperamide treatment.
ISSN:0361-9230
1873-2747
DOI:10.1016/s0361-9230(98)00048-3