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A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy results of the medicine versus angiography in thrombolytic exclusion (mate) trial
The purpose of this study was to determine if early triage angiography with revascularization, if indicated, favorably affects clinical outcomes in patients with suspected acute myocardial infarction who are ineligible for thrombolysis. The majority of patients with acute myocardial infarction and o...
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| Published in: | Journal of the American College of Cardiology 1998-09, Vol.32 (3), p.596-605 |
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| Main Authors: | , , , , , , , , , |
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| Language: | English |
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| container_title | Journal of the American College of Cardiology |
| container_volume | 32 |
| creator | MCCULLOUGH, P. A O'NEILL, W. W GRAHAM, M STOMEL, R. J ROGERS, F DAVID, S FARHAT, A KAZLAUSKAITE, R AL-ZAGOUM, M GRINES, C. L |
| description | The purpose of this study was to determine if early triage angiography with revascularization, if indicated, favorably affects clinical outcomes in patients with suspected acute myocardial infarction who are ineligible for thrombolysis.
The majority of patients with acute myocardial infarction and other acute coronary syndromes are considered ineligible for thrombolysis and therefore are not afforded the opportunity for early reperfusion.
This multicenter, prospective, randomized trial evaluated in a controlled fashion the outcomes following triage angiography in acute coronary syndromes ineligible for thrombolytic therapy. Eligible patients (n=201) with |
| doi_str_mv | 10.1016/S0735-1097(98)00284-8 |
| format | article |
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The majority of patients with acute myocardial infarction and other acute coronary syndromes are considered ineligible for thrombolysis and therefore are not afforded the opportunity for early reperfusion.
This multicenter, prospective, randomized trial evaluated in a controlled fashion the outcomes following triage angiography in acute coronary syndromes ineligible for thrombolytic therapy. Eligible patients (n=201) with <24 h of symptoms were randomized to early triage angiography and subsequent therapies based on the angiogram versus conventional medical therapy consisting of aspirin, intravenous heparin, nitroglycerin, beta-blockers, and analgesics.
In the triage angiography group, 109 patients underwent early angiography and 64 (58%) received revascularization, whereas in the conservative group, 54 (60%) subsequently underwent nonprotocol angiography in response to recurrent ischemia and 33 (37%) received revascularization (p=0.004). The mean time to revascularization was 27+/-32 versus 88+/-98 h (p=0.0001) and the primary endpoint of recurrent ischemic events or death occurred in 14 (13%) versus 31 (34%) of the triage angiography and conservative groups, respectively (45% risk reduction, 95% CI 27-59%, p=0.0002). There were no differences between the groups with respect to initial hospital costs or length of stay. Long-term follow-up at a median of 21 months revealed no significant differences in the endpoints of late revascularization, recurrent myocardial infarction, or all-cause mortality.
Early triage angiography in patients with acute coronary syndromes who are not eligible for thrombolytics reduced the composite of recurrent ischemic events or death and shortened the time to definitive revascularization during the index hospitalization. Despite more frequent early revascularization after triage angiography, we found no long-term benefit in cardiac outcomes compared with conservative medical therapy with revascularization prompted by recurrent ischemia.</description><identifier>ISSN: 0735-1097</identifier><identifier>EISSN: 1558-3597</identifier><identifier>DOI: 10.1016/S0735-1097(98)00284-8</identifier><identifier>PMID: 9741499</identifier><identifier>CODEN: JACCDI</identifier><language>eng</language><publisher>New York, NY: Elsevier Science</publisher><subject>Adult ; Aged ; Biological and medical sciences ; Cardiovascular system ; Cause of Death ; Coronary Angiography ; Coronary Disease - diagnostic imaging ; Coronary Disease - mortality ; Coronary Disease - therapy ; Female ; Hospital Mortality ; Humans ; Investigative techniques, diagnostic techniques (general aspects) ; Male ; Medical sciences ; Middle Aged ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - mortality ; Myocardial Infarction - therapy ; Myocardial Revascularization ; Prognosis ; Prospective Studies ; Radiodiagnosis. Nmr imagery. Nmr spectrometry ; Sensitivity and Specificity ; Thrombolytic Therapy ; Treatment Outcome ; Triage</subject><ispartof>Journal of the American College of Cardiology, 1998-09, Vol.32 (3), p.596-605</ispartof><rights>1998 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=2371575$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/9741499$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>MCCULLOUGH, P. A</creatorcontrib><creatorcontrib>O'NEILL, W. W</creatorcontrib><creatorcontrib>GRAHAM, M</creatorcontrib><creatorcontrib>STOMEL, R. J</creatorcontrib><creatorcontrib>ROGERS, F</creatorcontrib><creatorcontrib>DAVID, S</creatorcontrib><creatorcontrib>FARHAT, A</creatorcontrib><creatorcontrib>KAZLAUSKAITE, R</creatorcontrib><creatorcontrib>AL-ZAGOUM, M</creatorcontrib><creatorcontrib>GRINES, C. L</creatorcontrib><title>A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy results of the medicine versus angiography in thrombolytic exclusion (mate) trial</title><title>Journal of the American College of Cardiology</title><addtitle>J Am Coll Cardiol</addtitle><description>The purpose of this study was to determine if early triage angiography with revascularization, if indicated, favorably affects clinical outcomes in patients with suspected acute myocardial infarction who are ineligible for thrombolysis.
The majority of patients with acute myocardial infarction and other acute coronary syndromes are considered ineligible for thrombolysis and therefore are not afforded the opportunity for early reperfusion.
This multicenter, prospective, randomized trial evaluated in a controlled fashion the outcomes following triage angiography in acute coronary syndromes ineligible for thrombolytic therapy. Eligible patients (n=201) with <24 h of symptoms were randomized to early triage angiography and subsequent therapies based on the angiogram versus conventional medical therapy consisting of aspirin, intravenous heparin, nitroglycerin, beta-blockers, and analgesics.
In the triage angiography group, 109 patients underwent early angiography and 64 (58%) received revascularization, whereas in the conservative group, 54 (60%) subsequently underwent nonprotocol angiography in response to recurrent ischemia and 33 (37%) received revascularization (p=0.004). The mean time to revascularization was 27+/-32 versus 88+/-98 h (p=0.0001) and the primary endpoint of recurrent ischemic events or death occurred in 14 (13%) versus 31 (34%) of the triage angiography and conservative groups, respectively (45% risk reduction, 95% CI 27-59%, p=0.0002). There were no differences between the groups with respect to initial hospital costs or length of stay. Long-term follow-up at a median of 21 months revealed no significant differences in the endpoints of late revascularization, recurrent myocardial infarction, or all-cause mortality.
Early triage angiography in patients with acute coronary syndromes who are not eligible for thrombolytics reduced the composite of recurrent ischemic events or death and shortened the time to definitive revascularization during the index hospitalization. Despite more frequent early revascularization after triage angiography, we found no long-term benefit in cardiac outcomes compared with conservative medical therapy with revascularization prompted by recurrent ischemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Biological and medical sciences</subject><subject>Cardiovascular system</subject><subject>Cause of Death</subject><subject>Coronary Angiography</subject><subject>Coronary Disease - diagnostic imaging</subject><subject>Coronary Disease - mortality</subject><subject>Coronary Disease - therapy</subject><subject>Female</subject><subject>Hospital Mortality</subject><subject>Humans</subject><subject>Investigative techniques, diagnostic techniques (general aspects)</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>Myocardial Infarction - diagnostic imaging</subject><subject>Myocardial Infarction - mortality</subject><subject>Myocardial Infarction - therapy</subject><subject>Myocardial Revascularization</subject><subject>Prognosis</subject><subject>Prospective Studies</subject><subject>Radiodiagnosis. Nmr imagery. Nmr spectrometry</subject><subject>Sensitivity and Specificity</subject><subject>Thrombolytic Therapy</subject><subject>Treatment Outcome</subject><subject>Triage</subject><issn>0735-1097</issn><issn>1558-3597</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1998</creationdate><recordtype>article</recordtype><recordid>eNpdUU1LxDAQDaLo-vEThBxE9FBNmqZpjsviFwge1POSptPdSNqsSbpYf6C_y6DLgp4ymffmzcwbhE4puaKEltfPRDCeUSLFhawuCcmrIqt20IRyXmWMS7GLJlvKAToM4Y0QUlZU7qN9KQpaSDlBX1O88i6sQEezBuxV37jOfEKDozfKYtf-BAvAql8Yt_BqtRyx6bHSQwSsnXe98iMOY99410FIGFizMLUF3DqP4zKla2fHaHT6QBIYsYcw2Bh-1JeAO2iMTnV4DT4M4X-rPxLwoe0QjOvxRaciXP7OeYz2WmUDnGzeI_R6e_Myu88en-4eZtPHbJmXMmZct1CWBahS14WWHHRVsVrkigMDzfOmkECboqaQ5xyEqlklSdm2pICWSELYETr_1U2mvQ8Q4rwzQYO1qgc3hLlgMt2mzBPxdEMc6rTefOVNl3yab4xP-NkGV0Er2ybjtQlbWs4E5YKzb0aNmh0</recordid><startdate>19980901</startdate><enddate>19980901</enddate><creator>MCCULLOUGH, P. A</creator><creator>O'NEILL, W. W</creator><creator>GRAHAM, M</creator><creator>STOMEL, R. J</creator><creator>ROGERS, F</creator><creator>DAVID, S</creator><creator>FARHAT, A</creator><creator>KAZLAUSKAITE, R</creator><creator>AL-ZAGOUM, M</creator><creator>GRINES, C. L</creator><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19980901</creationdate><title>A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy results of the medicine versus angiography in thrombolytic exclusion (mate) trial</title><author>MCCULLOUGH, P. A ; O'NEILL, W. W ; GRAHAM, M ; STOMEL, R. J ; ROGERS, F ; DAVID, S ; FARHAT, A ; KAZLAUSKAITE, R ; AL-ZAGOUM, M ; GRINES, C. L</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h269t-5cfe664ea6cb4c95ec883b72a5e3ec52d49e1d4b1e225e7ab38906ff04ef09003</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1998</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Biological and medical sciences</topic><topic>Cardiovascular system</topic><topic>Cause of Death</topic><topic>Coronary Angiography</topic><topic>Coronary Disease - diagnostic imaging</topic><topic>Coronary Disease - mortality</topic><topic>Coronary Disease - therapy</topic><topic>Female</topic><topic>Hospital Mortality</topic><topic>Humans</topic><topic>Investigative techniques, diagnostic techniques (general aspects)</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>Myocardial Infarction - diagnostic imaging</topic><topic>Myocardial Infarction - mortality</topic><topic>Myocardial Infarction - therapy</topic><topic>Myocardial Revascularization</topic><topic>Prognosis</topic><topic>Prospective Studies</topic><topic>Radiodiagnosis. Nmr imagery. Nmr spectrometry</topic><topic>Sensitivity and Specificity</topic><topic>Thrombolytic Therapy</topic><topic>Treatment Outcome</topic><topic>Triage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>MCCULLOUGH, P. A</creatorcontrib><creatorcontrib>O'NEILL, W. W</creatorcontrib><creatorcontrib>GRAHAM, M</creatorcontrib><creatorcontrib>STOMEL, R. J</creatorcontrib><creatorcontrib>ROGERS, F</creatorcontrib><creatorcontrib>DAVID, S</creatorcontrib><creatorcontrib>FARHAT, A</creatorcontrib><creatorcontrib>KAZLAUSKAITE, R</creatorcontrib><creatorcontrib>AL-ZAGOUM, M</creatorcontrib><creatorcontrib>GRINES, C. L</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of the American College of Cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>MCCULLOUGH, P. A</au><au>O'NEILL, W. W</au><au>GRAHAM, M</au><au>STOMEL, R. J</au><au>ROGERS, F</au><au>DAVID, S</au><au>FARHAT, A</au><au>KAZLAUSKAITE, R</au><au>AL-ZAGOUM, M</au><au>GRINES, C. L</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy results of the medicine versus angiography in thrombolytic exclusion (mate) trial</atitle><jtitle>Journal of the American College of Cardiology</jtitle><addtitle>J Am Coll Cardiol</addtitle><date>1998-09-01</date><risdate>1998</risdate><volume>32</volume><issue>3</issue><spage>596</spage><epage>605</epage><pages>596-605</pages><issn>0735-1097</issn><eissn>1558-3597</eissn><coden>JACCDI</coden><abstract>The purpose of this study was to determine if early triage angiography with revascularization, if indicated, favorably affects clinical outcomes in patients with suspected acute myocardial infarction who are ineligible for thrombolysis.
The majority of patients with acute myocardial infarction and other acute coronary syndromes are considered ineligible for thrombolysis and therefore are not afforded the opportunity for early reperfusion.
This multicenter, prospective, randomized trial evaluated in a controlled fashion the outcomes following triage angiography in acute coronary syndromes ineligible for thrombolytic therapy. Eligible patients (n=201) with <24 h of symptoms were randomized to early triage angiography and subsequent therapies based on the angiogram versus conventional medical therapy consisting of aspirin, intravenous heparin, nitroglycerin, beta-blockers, and analgesics.
In the triage angiography group, 109 patients underwent early angiography and 64 (58%) received revascularization, whereas in the conservative group, 54 (60%) subsequently underwent nonprotocol angiography in response to recurrent ischemia and 33 (37%) received revascularization (p=0.004). The mean time to revascularization was 27+/-32 versus 88+/-98 h (p=0.0001) and the primary endpoint of recurrent ischemic events or death occurred in 14 (13%) versus 31 (34%) of the triage angiography and conservative groups, respectively (45% risk reduction, 95% CI 27-59%, p=0.0002). There were no differences between the groups with respect to initial hospital costs or length of stay. Long-term follow-up at a median of 21 months revealed no significant differences in the endpoints of late revascularization, recurrent myocardial infarction, or all-cause mortality.
Early triage angiography in patients with acute coronary syndromes who are not eligible for thrombolytics reduced the composite of recurrent ischemic events or death and shortened the time to definitive revascularization during the index hospitalization. Despite more frequent early revascularization after triage angiography, we found no long-term benefit in cardiac outcomes compared with conservative medical therapy with revascularization prompted by recurrent ischemia.</abstract><cop>New York, NY</cop><pub>Elsevier Science</pub><pmid>9741499</pmid><doi>10.1016/S0735-1097(98)00284-8</doi><tpages>10</tpages></addata></record> |
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| ispartof | Journal of the American College of Cardiology, 1998-09, Vol.32 (3), p.596-605 |
| issn | 0735-1097 1558-3597 |
| language | eng |
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| source | BACON - Elsevier - GLOBAL_SCIENCEDIRECT-OPENACCESS |
| subjects | Adult Aged Biological and medical sciences Cardiovascular system Cause of Death Coronary Angiography Coronary Disease - diagnostic imaging Coronary Disease - mortality Coronary Disease - therapy Female Hospital Mortality Humans Investigative techniques, diagnostic techniques (general aspects) Male Medical sciences Middle Aged Myocardial Infarction - diagnostic imaging Myocardial Infarction - mortality Myocardial Infarction - therapy Myocardial Revascularization Prognosis Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Sensitivity and Specificity Thrombolytic Therapy Treatment Outcome Triage |
| title | A prospective randomized trial of triage angiography in acute coronary syndromes ineligible for thrombolytic therapy results of the medicine versus angiography in thrombolytic exclusion (mate) trial |
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