Cortical motor neuron excitability during cutaneous silent period

• Published in: Electroencephalography and clinical neurophysiology 1998-08, Vol.109 (4), p.364-368
• Main Authors: Kaneko, Kazuo, Kawai, Shinya, Taguchi, Toshihiko, Fuchigami, Yasunori, Yonemura, Hiroshi, Fujimoto, Hideaki
• Format: Article
• Language: English
• Subjects: Adult; Biological and medical sciences; Cerebrospinal fluid. Meninges. Spinal cord; Conditioning (Psychology) - physiology; Electric Stimulation; Evoked Potentials, Motor; Excitatory Postsynaptic Potentials - physiology; Humans; Magnetics; Male; Medical sciences; Motor neuron; Motor Neurons - physiology; Muscle Contraction - physiology; Nervous system (semeiology, syndromes); Neurology; Pain; Pain - diagnosis; Pain - physiopathology; Peripheral Nerves - physiology; Silent period; Skin - innervation; Syringomyelia; Syringomyelia - diagnosis; Syringomyelia - physiopathology; Transcranial magnetic stimulation
• ISSN: 0924-980X; 0013-4694; 1872-7093
• DOI: 10.1016/S0924-980X(98)00031-9

Objective: To investigate cortical motor neuron excitability during cutaneous silent period (CSP), motor evoked potentials (MEPs) from abductor pollicis brevis following transcranial magnetic stimulation (TCM) were recorded with and without a conditioning of ipsilateral painful digital nerve electric stimulation. Methods: MEPs following TCM were recorded with and without a conditioning stimulation at an interstimulus interval (ISI) from 0 ms to 100ms in 6 controls and four patients who had reduced pain sensation in unilateral upper limbs associated with cervical syringomyelia. In addition MEPs and evoked spinal cord potentials (ESCPs) from cervical epidural space following TCM with and without a conditioning stimulation were recorded in four patients with thoracic myelopathy. Results: MEP amplitude was clearly attenuated by a conditioning stimulation at an ISI from 40 ms to 80 ms in controls (statistically significant at 60 ms). In patients with cervical syringomyelia, MEP amplitude was attenuated by a conditioning stimulation in asymptomatic hands similarly in controls but that was unchanged by a conditioning stimulation in the symptomatic hand with reduced pain sensation. In patients with thoracic myelopathy MEP amplitude was attenuated by conditioning stimulation similarly in controls, but ESCP amplitude was unchanged. Conclusions: We demonstrated that noxious cutaneous nerve stimulation suppressed spinal motor neurons but cortical motor neuron excitability was unchanged during CSP. In clinical practice, measurement of MEP suppression after noxious cutaneous nerve stimulation may provide useful information in patients with damaged pain related nerve fibers.