Sympathetic activity in obese subjects with and without obstructive sleep apnea

Obese humans are reported to have increased muscle sympathetic nerve activity (MSNA). Obstructive sleep apnea (OSA) may also be accompanied by increased MSNA. Because there is a high prevalence of OSA in obese humans, it is possible that high MSNA reported in obese subjects may in fact reflect the p...

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Bibliographic Details
Published in:Circulation (New York, N.Y.) N.Y.), 1998-08, Vol.98 (8), p.772-776
Main Authors: NARKIEWICZ, K, VAN DE BORNE, P. J. H, COOLEY, R. L, DYKEN, M. E, SOMERS, V. K
Format: Article
Language:English
Subjects:
Adult
Analysis of Variance
Biological and medical sciences
Case-Control Studies
Female
Humans
Linear Models
Male
Medical sciences
Metabolic diseases
Muscle, Skeletal - blood supply
Obesity
Obesity - physiopathology
Polysomnography
Prevalence
Reference Values
Sleep Apnea Syndromes - etiology
Sleep Apnea Syndromes - physiopathology
Sympathetic Nervous System - physiology
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Summary:Obese humans are reported to have increased muscle sympathetic nerve activity (MSNA). Obstructive sleep apnea (OSA) may also be accompanied by increased MSNA. Because there is a high prevalence of OSA in obese humans, it is possible that high MSNA reported in obese subjects may in fact reflect the presence of OSA in these subjects. We tested the hypothesis that obesity, per se, in the absence of OSA, is not accompanied by increased MSNA. We measured MSNA in 25 healthy normal-weight subjects and 30 healthy sedentary obese subjects. All subjects were screened by history and examination to exclude subjects with OSA or hypertension. OSA was further excluded by overnight polysomnographic studies. Despite careful screening, polysomnography revealed that 1 of 25 normal-weight subjects and 9 of 30 obese subjects had occult OSA (P=0.015). MSNA was similar in normal-weight subjects (41+/-3 bursts per 100 heartbeats) and obese subjects without sleep apnea (42+/-3 bursts per 100 heartbeats, P=0.99). MSNA in the 9 obese subjects with occult OSA was 61+/-8 bursts per 100 heartbeats, which was higher than MSNA in normal-weight subjects without sleep apnea (P=0.02) and higher than MSNA in obese subjects without sleep apnea (P=0.02). Obesity alone, in the absence of OSA, is not accompanied by increased sympathetic activity to muscle blood vessels.
ISSN:0009-7322
1524-4539
DOI:10.1161/01.CIR.98.8.772