Population pharmacokinetic analysis of mexiletine in adult arrhythmic patients in Japanese population

We analyzed mexiletine in Japanese patients using population pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to...

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Bibliographic Details
Published in:Biological & pharmaceutical bulletin 1998, Vol.21 (8), p.844-846
Main Authors: UENAKA, K, KOUE, T, IWAI, T, SHIBAKAWA, M, UENO, K
Format: Article
Language:English
Subjects:
Adult
Age Factors
Aged
Aged, 80 and over
Anti-Arrhythmia Agents - pharmacokinetics
Antiarythmic agents
Arrhythmias, Cardiac - drug therapy
Arrhythmias, Cardiac - metabolism
Biological and medical sciences
Cardiovascular system
Female
Humans
Male
Medical sciences
Mexiletine - pharmacokinetics
Middle Aged
Pharmacology. Drug treatments
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Summary:We analyzed mexiletine in Japanese patients using population pharmacokinetics. 139 serum concentration data, which were collected for therapeutic drug monitoring from 121 patients, were used for this analysis. We also investigated influence of age and gender on pharmacokinetics, and age was found to be an influential factor on clearance. The final pharmacokinetic parameters are, CL/F=0.580-0.00369 x AGE (l/h/kg) and Vd/F=6.63 (l/kg). These results should be useful for adjusting the dosage to a patient's age for the prevention of an adverse reaction caused by overexposure.
ISSN:0918-6158
1347-5215
DOI:10.1248/bpb.21.844