Glutamate Release Monitored with Astrocyte Transporter Currents during LTP

Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural...

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Bibliographic Details
Published in:Neuron (Cambridge, Mass.) Mass.), 1998-08, Vol.21 (2), p.425-433
Main Authors: Diamond, Jeffrey S, Bergles, Dwight E, Jahr, Craig E
Format: Article
Language:English
Subjects:
Animals
Astrocytes - physiology
Biological Transport - physiology
Excitatory Postsynaptic Potentials
Glutamic Acid - metabolism
Hippocampus - cytology
Hippocampus - metabolism
In Vitro Techniques
Long-Term Potentiation
Nerve Endings - metabolism
Nerve Fibers - metabolism
Patch-Clamp Techniques
Rats
Rats, Sprague-Dawley
Synaptic Transmission - physiology
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Summary:Long-term potentiation (LTP) of synaptic transmission in the CA1 region of the hippocampus is thought to result from either increased transmitter release, heightened postsynaptic sensitivity, or a combination of the two. We have measured evoked glutamate release from Schaffer collateral/commissural fiber terminals in CA1 by recording synaptically activated glutamate transporter currents in hippocampal astrocytes located in stratum radiatum. Although several manipulations of release probability caused parallel changes in extracellular field potentials and synaptically activated transporter current amplitudes, induction of LTP failed to alter transporter-mediated responses, suggesting that LTP does not alter the amount of glutamate released upon synaptic stimulation.
ISSN:0896-6273
1097-4199
DOI:10.1016/S0896-6273(00)80551-6