IL-10 reduces rat brain injury following focal stroke

• Published in: Neuroscience letters 1998-07, Vol.251 (3), p.189-192
• Main Authors: Spera, Patricia A., Ellison, Julie A., Feuerstein, Giora Z., Barone, Frank C.
• Format: Article
• Language: English
• Subjects: Animals; Anti-Inflammatory Agents - administration & dosage; Anti-Inflammatory Agents - pharmacology; Biological and medical sciences; Brain injury; Cerebral Infarction - etiology; Cerebral Infarction - pathology; Cerebral Infarction - prevention & control; Cerebral ischemia; Cytokines; Focal stroke; Humans; IL-10; Inflammation; Injections, Intravenous; Injections, Intraventricular; Interleukin-10 - administration & dosage; Interleukin-10 - pharmacology; Ischemic Attack, Transient - complications; Ischemic Attack, Transient - pathology; Ischemic Attack, Transient - prevention & control; Medical sciences; Neuropharmacology; Neuroprotection; Neuroprotective agent; Neuroprotective Agents - administration & dosage; Neuroprotective Agents - pharmacology; Pharmacology. Drug treatments; Rats; Rats, Inbred SHR; Recombinant Proteins - administration & dosage; Recombinant Proteins - pharmacology
• ISSN: 0304-3940; 1872-7972
• DOI: 10.1016/S0304-3940(98)00537-0

The effects of the anti-inflammatory cytokine, IL-10, on brain injury following permanent focal ischemia were determined. Rats subjected to occlusion of the right middle cerebral artery (MCAO) were administered IL-10 (1 μg) centrally into the lateral ventricle 30 min and 3 h post MCAO or systemically into the tail vein (5 or 15 μg/h) starting 30 min post MCAO for 3 h. Brains were removed 24 h later and infarct size was measured. IL-10 administered centrally significantly ( P