Interactions between Mycobacterium tuberculosis and host cells: are mycobacterial sugars the key?

Mycobacterium tuberculosis has evolved successful strategies to invade and persist within macrophages. Intimate pathogen–macrophage contacts dictate receptor choice and probably specify the intracellular fate of these microrganisms. Binding to specific receptors, such as complement receptor type 3,...

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Bibliographic Details
Published in:Trends in microbiology (Regular ed.) 1998-08, Vol.6 (8), p.328-335
Main Authors: Ehlers, Mario R.W, Daffé, Mamadou
Format: Article
Language:English
Subjects:
Animals
capsule
Carbohydrate Metabolism
CR3
Humans
macrophage
Macrophage-1 Antigen - metabolism
Mannose - metabolism
MBP
Mycobacterium
Mycobacterium tuberculosis
Mycobacterium tuberculosis - metabolism
Mycobacterium tuberculosis - physiology
PIM
Receptors, Cell Surface - metabolism
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Summary:Mycobacterium tuberculosis has evolved successful strategies to invade and persist within macrophages. Intimate pathogen–macrophage contacts dictate receptor choice and probably specify the intracellular fate of these microrganisms. Binding to specific receptors, such as complement receptor type 3, could provide an advantage. These interactions appear to involve surface polysaccharides and glycolipids.
ISSN:0966-842X
1878-4380
DOI:10.1016/S0966-842X(98)01301-8