Immunohistochemical and ultrastructural evidence of hog cholera virus infection of megakaryocytes in bone marrow and spleen

Twelve pigs were inoculated with a highly virulent strain of hog cholera virus (HCV) to study viral infection of megakaryocytes in the bone marrow and spleen. Immunohistochemical and ultrastructural examination revealed HCV infection in a small proportion (2·5–9·0%) of these cells from the 2nd to th...

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Bibliographic Details
Published in:Journal of comparative pathology 1998-08, Vol.119 (2), p.111-119
Main Authors: Gómez-Villamandos, J.C., Ruiz-Villamor, E., Salguero, F.J., Bautista, M.J., Carrasco, L., Sánchez, C., Quezada, M., Sierra, M.A.
Format: Article
Language:English
Subjects:
Animals
Antigens, Viral - analysis
Bone Marrow - pathology
Bone Marrow - virology
Cell Count
Classical Swine Fever - pathology
Classical Swine Fever - virology
Classical Swine Fever Virus - physiology
Classical Swine Fever Virus - ultrastructure
Female
Immunoenzyme Techniques - veterinary
Inclusion Bodies - ultrastructure
Male
Megakaryocytes - ultrastructure
Megakaryocytes - virology
Platelet Count - veterinary
Spleen - pathology
Spleen - virology
Swine
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Summary:Twelve pigs were inoculated with a highly virulent strain of hog cholera virus (HCV) to study viral infection of megakaryocytes in the bone marrow and spleen. Immunohistochemical and ultrastructural examination revealed HCV infection in a small proportion (2·5–9·0%) of these cells from the 2nd to the 9th day after inoculation, at which time the experiment was terminated. Megakaryocyte infection accounts for the presence of viral antigens in platelets. The latter may represent a passive vehicle for spreading the virus in the animal.
ISSN:0021-9975
1532-3129
DOI:10.1016/S0021-9975(98)80056-X