Risk of Uterine Leiomyomata among Premenopausal Women in Relation to Body Size and Cigarette Smoking

To investigate whether factors influencing ovarian function affect risk of uterine leiomyomata, we examined prospectively the association of new diagnoses confirmed by ultrasound or hysterectomy with body mass index, weight change, height, and cigarette smoking among 94,095 premenopausal women with...

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Bibliographic Details
Published in:Epidemiology (Cambridge, Mass.) Mass.), 1998-09, Vol.9 (5), p.511-517
Main Authors: Marshall, Lynn M., Spiegelman, Donna, Manson, JoAnn E., Goldman, Marlene B., Barbieri, Robert L., Stampfer, Meir J., Willett, Walter C., Hunter, David J.
Format: Article
Language:English
Subjects:
Adult
Age
Biological and medical sciences
Body Constitution
Body mass index
Body size
Cigarette smoking
Cohort Studies
Epidemiology
Female
Female genital diseases
Gynecology. Andrology. Obstetrics
Humans
Hysterectomy
Leiomyoma
Leiomyoma - epidemiology
Medical sciences
Nurses
Obesity
Premenopause
Prospective Studies
Questionnaires
Risk
Risk Factors
Smoking - epidemiology
Tumors
Ultrasonography
United States - epidemiology
Uterine Neoplasms - epidemiology
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Summary:To investigate whether factors influencing ovarian function affect risk of uterine leiomyomata, we examined prospectively the association of new diagnoses confirmed by ultrasound or hysterectomy with body mass index, weight change, height, and cigarette smoking among 94,095 premenopausal women with intact uteri, who were ages 25-42 years at the start of follow-up in 1989. We assessed body mass index and cigarette smoking from responses on the study questionnaire completed just before diagnosis. During 322,775 person-years, 2,967 new cases of uterine leiomyomata confirmed by ultrasound or hysterectomy were reported. Risk among all cases confirmed by ultrasound or hysterectomy increased with increasing adult body mass index. The multivariate relative risks (RR) and 95% confidence intervals (CI) according to body mass index categories of
ISSN:1044-3983
1531-5487
DOI:10.1097/00001648-199809000-00007