α-adrenergic activation of phosphorylase in liver cells involves mobilization of intracellular calcium without influx of extracellular calcium

It is concluded from these studies that the activation of hepatic phosphorylase by alpha -adrenergic agonists, vasopressin, and mitochondrial inhibitors does not involve an influx of external Ca super(2+) and that the mobilization of intracellular Ca super(2+) pools such as mitochondria and perhaps...

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Bibliographic Details
Published in:The Journal of biological chemistry 1982-01, Vol.257 (1), p.190-197
Main Authors: BLACKMORE, P. F, HUGHES, B. P, SHUMAN, E. A, EXTON, J. H
Format: Article
Language:English
Subjects:
alpha -adrenergic
Animals
Biological and medical sciences
calcium
Calcium - metabolism
Cell physiology
Cyclic AMP - metabolism
Egtazic Acid - pharmacology
Enzyme Activation
Fundamental and applied biological sciences. Psychology
hepatocytes
Kinetics
Liver - metabolism
mitochondria
Molecular and cellular biology
Neurotransmission
Oligomycins - pharmacology
Phenoxybenzamine - pharmacology
Phenylephrine - pharmacology
phosphorylase
Phosphorylase a - metabolism
Phosphorylases - metabolism
Rats
Tetracaine - pharmacology
Vasopressins - pharmacology
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Summary:It is concluded from these studies that the activation of hepatic phosphorylase by alpha -adrenergic agonists, vasopressin, and mitochondrial inhibitors does not involve an influx of external Ca super(2+) and that the mobilization of intracellular Ca super(2+) pools such as mitochondria and perhaps endoplasmic reticulum and plasma membrane, is sufficiently rapid to account for the metabolic changes observed. The similarity between the effects of alpha -agonists, vasopressin, and mitochondrial inhibitors, and their non-additivity at maximally effective concentrations, suggests that they mobilize Ca super(2+) from a common intracellular pool(s) and that this is mitochondrial in part.
ISSN:0021-9258
1083-351X
DOI:10.1016/s0021-9258(19)68345-6