A superfamily of proteins that contain the cold-shock domain

Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial domain and appear to function as RNA-chaperones. They have been implicated in various cellular processes, including adaptation to low temperatures, cellular growth, nutrient stress and stationary phase. The discov...

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Bibliographic Details
Published in:Trends in biochemical sciences (Amsterdam. Regular ed.) 1998-08, Vol.23 (8), p.286-290
Main Authors: Graumann, Peter L., Marahiel, Mohamed A.
Format: Article
Language:English
Subjects:
Bacterial Proteins - chemistry
Bacterial Proteins - physiology
Cold Temperature
cold-shock domain
cold-shock proteins
Eukaryotic Cells - physiology
evolution
Evolution, Molecular
Gene Expression Regulation, Bacterial
Models, Molecular
OB-fold
Protein Conformation
RNA Processing, Post-Transcriptional
RNA-binding
RNA-Binding Proteins - chemistry
RNA-Binding Proteins - physiology
RNA-chaperone
Space life sciences
Transcription Factors - chemistry
Transcription Factors - physiology
Xenopus Proteins
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Summary:Members of a family of cold-shock proteins (CSPs) are found throughout the eubacterial domain and appear to function as RNA-chaperones. They have been implicated in various cellular processes, including adaptation to low temperatures, cellular growth, nutrient stress and stationary phase. The discovery of a domain—the cold-shock domain—that shows strikingly high homology and similar RNA-binding properties to CSPs in a growing number of eukaryotic nucleic-acid-binding proteins suggests that these proteins have an ancient origin.
ISSN:0968-0004
1362-4326
DOI:10.1016/S0968-0004(98)01255-9