Refined radiation hybrid map of mouse chromosome 17

We have made a radiation hybrid map of mouse Chromosome (Chr) 17 with 75 microsatellite markers, including those from McCarthy et al. (Genome Res 7, 1153-1161, 1997). Seventy-four of the markers are linked at LOD > 9, and all link at LOD > 5. A LOD 3 framework of 18 markers was used to constru...

Full description

Saved in:
Bibliographic Details
Published in:Mammalian genome 1998-10, Vol.9 (10), p.807-811
Main Authors: Schalkwyk, L C, Weiher, M, Kirby, M, Cusack, B, Himmelbauer, H, Lehrach, H
Format: Article
Language:English
Subjects:
Animals
Cricetinae
Crosses, Genetic
Female
Genetic Linkage
Genetics
Hybrid Cells
Male
Mice - genetics
Microsatellite Repeats
Muridae
Physical Chromosome Mapping - methods
Recombination, Genetic
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We have made a radiation hybrid map of mouse Chromosome (Chr) 17 with 75 microsatellite markers, including those from McCarthy et al. (Genome Res 7, 1153-1161, 1997). Seventy-four of the markers are linked at LOD > 9, and all link at LOD > 5. A LOD 3 framework of 18 markers was used to construct a placement map. The order obtained is in good agreement with genetic maps, and distance estimates give an idea of how recombination rates vary across the chromosome. Recombination is remarkably low with respect to RH break frequency in the region from the centromere to the end of H2. This is similar in interspecific and intersubspecific crosses despite the inversion of a substantial part of this region in Mus spretus with respect to Mus musculus.
ISSN:0938-8990
1432-1777
DOI:10.1007/s003359900871