Inhibition of 5-HT3 receptor cation channels by ifenprodil in excised patches of N1E-115 cells

The patch-clamp technique was applied in out-side-out patches of N1E-115 mouse neuroblastoma cells to investigate the effects of ifenprodil [(+/-) erythreo-ifenprodil tartratel, a drug with neuroprotective properties in cerebral ischemia, on the inward currents through 5-HT3 receptor channels. A hig...

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Bibliographic Details
Published in:Naunyn-Schmiedeberg's archives of pharmacology 1998-08, Vol.358 (2), p.145-152
Main Authors: Barann, M, Bönisch, H, Urban, B W, Göthert, M
Format: Article
Language:English
Subjects:
Adrenergic alpha-Antagonists - pharmacology
Animals
Dose-Response Relationship, Drug
Electrophysiology
Free Radical Scavengers - pharmacology
Kinetics
Membrane Potentials - drug effects
Patch-Clamp Techniques
Piperidines - pharmacology
Receptors, Serotonin - drug effects
Receptors, Serotonin, 5-HT3
Serotonin - pharmacology
Sodium Channels - drug effects
Sodium Channels - physiology
Tumor Cells, Cultured - cytology
Tumor Cells, Cultured - drug effects
Tumor Cells, Cultured - physiology
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Summary:The patch-clamp technique was applied in out-side-out patches of N1E-115 mouse neuroblastoma cells to investigate the effects of ifenprodil [(+/-) erythreo-ifenprodil tartratel, a drug with neuroprotective properties in cerebral ischemia, on the inward currents through 5-HT3 receptor channels. A high time resolution was achieved by using a rapid solution exchange system (exchange rate
ISSN:0028-1298
DOI:10.1007/PL00005236