HLA-B27-negative sacroiliitis: a manifestation of familial Mediterranean fever in childhood

Familial Mediterranean fever is a polysystemic disease seen most frequently in persons of Mediterranean ancestry. Arthritis is one of the common manifestations. Both symptomatic and asymptomatic sacroiliitis have been reported in adults. We report on two children with familial Mediterranean fever wi...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1978-03, Vol.61 (3), p.423-426
Main Authors: Lehman, T J, Hanson, V, Kornreich, H, Peters, R S, Schwabe, A D
Format: Article
Language:English
Subjects:
Arthritis - drug therapy
Arthritis - etiology
Arthritis - immunology
Child
Colchicine - therapeutic use
Familial Mediterranean Fever - complications
Familial Mediterranean Fever - diagnosis
Familial Mediterranean Fever - drug therapy
HLA Antigens
Humans
Male
Radiography
Sacroiliac Joint - diagnostic imaging
Sacroiliac Joint - immunology
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Description
Summary:Familial Mediterranean fever is a polysystemic disease seen most frequently in persons of Mediterranean ancestry. Arthritis is one of the common manifestations. Both symptomatic and asymptomatic sacroiliitis have been reported in adults. We report on two children with familial Mediterranean fever with radiographic abnormalities similar to those described in adults. Although sacroiliitis is strongly correlated with the presence of HLA-B27 in most arthropathies, these children were HLA-B27-negative. The diagnosis of familial Mediterranean fever was delayed in both patients because the association of sacroiliitis with familial Mediterranean fever in childhood was not recognized.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.61.3.423