A genome-wide search for schizophrenia susceptibility genes

We completed a systematic genome‐wide search for evidence of loci linked to schizophrenia using a collection of 70 pedigrees containing multiple affected individuals according to three phenotype classifications: schizophrenia only (48 pedigrees; 70 sib‐pairs); schizophrenia plus schizoaffective diso...

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Bibliographic Details
Published in:American journal of medical genetics 1998-09, Vol.81 (5), p.364-376
Main Authors: Shaw, Sarah H., Kelly, Mary, Smith, Angela B., Shields, Gail, Hopkins, Penelope J., Loftus, Josephine, Laval, Steven H., Vita, Antonio, De Hert, Marc, Cardon, Lon R., Crow, Timothy J., Sherrington, Robin, DeLisi, Lynn E.
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Biological and medical sciences
chromosome 13
chromosome 2
chromosome 22
chromosome 4
Chromosome Mapping
Female
Genetic Linkage
Genetic Markers
Genetic Predisposition to Disease
Genome, Human
Humans
linkage
Male
Medical sciences
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Psychoses
Schizophrenia
Schizophrenia - genetics
sib-pair analysis
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Summary:We completed a systematic genome‐wide search for evidence of loci linked to schizophrenia using a collection of 70 pedigrees containing multiple affected individuals according to three phenotype classifications: schizophrenia only (48 pedigrees; 70 sib‐pairs); schizophrenia plus schizoaffective disorder (70 pedigrees; 101 sib‐pairs); and a broad category consisting of schizophrenia, schizoaffective disorder, paranoid or schizotypal personality disorder, psychosis not otherwise specified (NOS), delusional disorder, and brief reactive psychosis (70 pedigrees; 111 sib‐pairs). All 70 families contained at least one individual affected with chronic schizophrenia according to DSM‐III‐R criteria. Three hundred and thirty‐eight markers spanning the genome were typed in all pedigrees for an average resolution of 10.5 cM (range, 0–31 cM) and an average heterozygosity of 74.3% per marker. The data were analyzed using multipoint nonparametric allele‐sharing and traditional two‐point lod score analyses using dominant and recessive, affecteds‐only models. Twelve chromosomes (1, 2, 4, 5, 8, 10, 11, 12, 13, 14, 16, and 22) had at least one region with a nominal P value
ISSN:0148-7299
1096-8628
DOI:10.1002/(SICI)1096-8628(19980907)81:5<364::AID-AJMG4>3.0.CO;2-T