Effects of neonatal focal cerebral hypoxia–ischemia on sleep–waking pattern, ECoG power spectra and locomotor activity in the adult rat

The aim of this study was to determine the influence of neonatal focal cerebral hypoxia–ischemia (HI) on sleep–waking pattern, electrocorticogram (ECoG) power spectra and locomotor activity (LA) in adult Wistar rats. Seven-day old pups were subjected to permanent unilateral ligation of the common ca...

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Bibliographic Details
Published in:Brain research 1998-10, Vol.807 (1), p.29-37
Main Authors: Antier, Daniel, Zhang, Bei-Li, Mailliet, François, Akoka, Serge, Pourcelot, Léandre, Sannajust, Frédéric
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Biological and medical sciences
Brain injury
Cortical EEG
Electroencephalography
Hypoxia, Brain - physiopathology
Ischemic Attack, Transient - physiopathology
Locomotor activity
Magnetic Resonance Imaging
Male
Medical sciences
Motor Activity - physiology
Neonatal cerebral hypoxia–ischemia
Neurology
Rat
Rats
Rats, Wistar
Sleep - physiology
Space life sciences
Telemetry
Vascular diseases and vascular malformations of the nervous system
Wakefulness - physiology
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Summary:The aim of this study was to determine the influence of neonatal focal cerebral hypoxia–ischemia (HI) on sleep–waking pattern, electrocorticogram (ECoG) power spectra and locomotor activity (LA) in adult Wistar rats. Seven-day old pups were subjected to permanent unilateral ligation of the common carotid artery and transient hypoxia (8% O 2). At 10 weeks of age, the extent of brain damages was evaluated by magnetic resonance imaging (MRI) and homogenous injured animals were selected before chronic implantation of radiotelemetry device. Using a single ECoG recording channel method, waking (W), paradoxical sleep (PS) and slow wave sleep (SWS) were continuously recorded for 72 h and they were semi-automatically analyzed off-line. We observed that neonatal HI triggers a cascade of events leading, in adult rats, to brain dysfunction characterized by an increase in SWS (55.0 vs. 40.2% in sham-operated rats, p
ISSN:0006-8993
1872-6240
DOI:10.1016/S0006-8993(98)00703-3