Target Cell-Specific Modulation of Transmitter Release at Terminals from a Single Axon

In the hippocampus, a CA3 pyramidal cell forms excitatory synapses with thousands of other pyramidal cells and inhibitory interneurons. By using sequential paired recordings from three connected cells, we show that the presynaptic properties of CA3 pyramidal cell terminals, belonging to the same axo...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 1998-09, Vol.95 (20), p.12004-12009
Main Authors: Scanziani, Massimo, Gähwiler, Beat H., Charpak, Serge
Format: Article
Language:English
Subjects:
Aminobutyrates - pharmacology
Animals
Axons
Axons - physiology
Biological Sciences
Brain
Electrophysiology
Excitatory Amino Acid Agonists - pharmacology
Hippocampus - cytology
Hippocampus - metabolism
Hippocampus - physiology
In Vitro Techniques
Interneurons
Interneurons - physiology
Nerve Endings - drug effects
Nerve Endings - metabolism
Neurology
Neurons
Neuroscience
Neurotransmitter Agents - metabolism
Pipettes
Purkinje cells
Pyramidal cells
Pyramidal Cells - physiology
Radio transmitters
Rats
Rats, Wistar
Receptors
Receptors, Metabotropic Glutamate - drug effects
Receptors, Metabotropic Glutamate - physiology
Synapses
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Description
Summary:In the hippocampus, a CA3 pyramidal cell forms excitatory synapses with thousands of other pyramidal cells and inhibitory interneurons. By using sequential paired recordings from three connected cells, we show that the presynaptic properties of CA3 pyramidal cell terminals, belonging to the same axon, differ according to the type of target cell. Activation of presynaptic group III metabotropic glutamate receptors decreases transmitter release only at terminals contacting CA1 interneurons but not CA1 pyramidal cells. Furthermore, terminals contacting distinct target cells show different frequency facilitation. On the basis of these results, we conclude that the pharmacological and physiological properties of presynaptic terminals are determined, at least in part, by the target cells.
ISSN:0027-8424
1091-6490
DOI:10.1073/pnas.95.20.12004