Mn blood groups and bipolar disorder: evidence of genotypic association and hardy–weinberg disequilibrium

Background: MN blood groups have been studied in the past as a genetic marker of bipolar disorder (BD). Several previous studies reported an association of the illness with lower frequency of blood group NN. Methods: We analyzed distribution of MN blood groups in a sample of 174 patients with BD, 17...

Full description

Saved in:
Bibliographic Details
Published in:Biological psychiatry (1969) 1998-09, Vol.44 (5), p.361-363
Main Authors: Alda, Martin, Grof, Paul, Grof, Eva
Format: Article
Language:English
Subjects:
Adult and adolescent clinical studies
Alleles
association
Biological and medical sciences
Bipolar disorder
Bipolar Disorder - blood
Bipolar Disorder - genetics
Bipolar disorders
Genotype
Hardy–Weinberg equilibrium
Humans
Linkage Disequilibrium
lithium
Medical sciences
MN blood groups
MNSs Blood-Group System - genetics
Mood disorders
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Schizophrenia - blood
Schizophrenia - genetics
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background: MN blood groups have been studied in the past as a genetic marker of bipolar disorder (BD). Several previous studies reported an association of the illness with lower frequency of blood group NN. Methods: We analyzed distribution of MN blood groups in a sample of 174 patients with BD, 176 with unipolar depression, 98 with schizophrenia, and 331 healthy controls. In addition, we tested whether the inferred genotypes conform to Hardy–Weinberg equilibrium (HWE). Results: The frequency of NN phenotype was significantly lower among the bipolar patients than in any of the other three groups ( p < .001). The genotype frequencies in the BD group deviated significantly from those expected under HWE ( p < .01). Conclusions: These results suggest a possible locus on chromosome 4 (4q28–q31.1) associated with genetic susceptibility to bipolar illness.
ISSN:0006-3223
1873-2402
DOI:10.1016/S0006-3223(98)00013-4