ABO hemolytic disease of the newborn: evaluation of management and identification of racial and antigenic factors

Data from 16,320 deliveries from two time periods were examined to compare the incidence of positive direct Coombs' tests and the number of exchange transfusions performed, using different methods of screening and treatment in each time period. Early routine screening revealed an eightfold incr...

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Bibliographic Details
Published in:Pediatrics (Evanston) 1978-03, Vol.61 (3), p.475-478
Main Authors: Peevy, K J, Wiseman, H J
Format: Article
Language:English
Subjects:
ABO Blood-Group System
African Continental Ancestry Group
Antigens
Coombs Test
Erythroblastosis, Fetal - blood
Erythroblastosis, Fetal - complications
Erythroblastosis, Fetal - diagnosis
European Continental Ancestry Group
Exchange Transfusion, Whole Blood
Female
Fetal Blood
Humans
Infant, Newborn
Jaundice, Neonatal - etiology
Jaundice, Neonatal - therapy
Phototherapy
Pregnancy
Retrospective Studies
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Summary:Data from 16,320 deliveries from two time periods were examined to compare the incidence of positive direct Coombs' tests and the number of exchange transfusions performed, using different methods of screening and treatment in each time period. Early routine screening revealed an eightfold increase in the number of Coombs-positive infants, while the combined effect of instituting early screening and the change from white light to special blue light phototherapy greatly diminihsed the number of exchange transfusions. In addition, data concerning racial and blood antigen factors in ABO hemolytic disease of the newborn (HDN) are compared, showing an increase in incidence but no increase in severity for black infants and infants with blood type B. Also, use of cord blood parameters in management of ABO HDN is discussed.
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.61.3.475