Extramedullary granulopoiesis mimicking recurrent lymphoma after prolonged administration of human recombinant granulocyte colony-stimulating factor

Human recombinant granulocyte colony-stimulating factor (G-CSF) has become a treatment of choice for neutropenia of diverse etiologies. We describe a 71-year-old man who, while receiving G-CSF for graft failure after peripheral blood stem cell transplant, developed dramatic extramedullary granulopoi...

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Bibliographic Details
Published in:Annals of hematology 1998-07, Vol.77 (1-2), p.79-83
Main Authors: FRIEDMAN, H. D, SANDERSON, S. O, STEIN, C. K, SHRIMPTON, A, GONCHOROFF, N. J, ZAMKOFF, K. W, LOUGHRAN, T. P
Format: Article
Language:English
Subjects:
Aged
Biological and medical sciences
Diagnosis, Differential
Etiology
Fusion Proteins, bcr-abl - analysis
Gene Rearrangement, B-Lymphocyte
Grafts
Granulocyte colony-stimulating factor
Granulocyte Colony-Stimulating Factor - administration & dosage
Granulocytes - cytology
Granulopoiesis
Hematologic and hematopoietic diseases
Hematopoiesis, Extramedullary
Histocytochemistry
Humans
Immunohistochemistry
In Situ Hybridization, Fluorescence
Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis
Leukopoiesis
Lymphoma
Lymphoma - genetics
Lymphoma, Non-Hodgkin - diagnosis
Lymphoma, Non-Hodgkin - physiopathology
Male
Medical sciences
Mimicry
Neutropenia
Peripheral blood
Polymerase Chain Reaction
Recombinant Proteins - administration & dosage
Rejection
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Description
Summary:Human recombinant granulocyte colony-stimulating factor (G-CSF) has become a treatment of choice for neutropenia of diverse etiologies. We describe a 71-year-old man who, while receiving G-CSF for graft failure after peripheral blood stem cell transplant, developed dramatic extramedullary granulopoiesis that mimicked recurrent lymphoma.
ISSN:0939-5555
1432-0584
DOI:10.1007/s002770050417