Inability of vitamin A deficiency to alter benzo(a)pyrene metabolism in Syrian hamsters

Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of benzo(a)pyrene were determined. The...

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Bibliographic Details
Published in:Cancer research (Chicago, Ill.) Ill.), 1978-06, Vol.38 (6), p.1497-1501
Main Authors: Bornstein, W A, Lamden, M P, Chuang, A H, Gross, R L, Newberne, P M, Bresnick, E
Format: Article
Language:English
Subjects:
Animals
Aryl Hydrocarbon Hydroxylases - metabolism
Benzopyrenes - metabolism
Cricetinae
In Vitro Techniques
Lung - metabolism
Male
Mesocricetus
Microsomes - metabolism
Vitamin A - analogs & derivatives
Vitamin A - pharmacology
Vitamin A Deficiency - metabolism
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Summary:Syrian golden hamsters were placed on a control or vitamin A-deficient diet. When their serum vitamin A content was significantly reduced, i.e., to less than 10% of controls, the hamsters were killed and lung aryl hydrocarbon hydroxylase activity and metabolism of benzo(a)pyrene were determined. The benzo(a)pyrene metabolite profile was similar with control and A-deficient systems, and only few quantitative differences were noted. Addition of beta-retinyl acetate to the in vitro incubations did not substantially affect benzo(a)pyrene metabolism.
ISSN:0008-5472