Progesterone monoclonal antibody blocks pregnancy in mice

Production of monoclonal antibodies by hybrid cell lines 1 provides a method potentially superior to conventional techniques for raising antisera 2 in respect of titre and specificity. Many lines have been prepared 3 that secrete antibody to cell-surface and soluble antigens and to viruses, but the...

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Bibliographic Details
Published in:Nature (London) 1982-02, Vol.295 (5848), p.415-417
Main Authors: Wright, L.J, Feinstein, A, Heap, R.B, Saunders, J.C, Bennett, R.C, Wang, M.Y
Format: Article
Language:English
Subjects:
animal physiology
animal reproduction
Animals
Antibodies, Monoclonal - immunology
Antibody Specificity
Embryonic Development
Female
Humanities and Social Sciences
letter
Mice
multidisciplinary
Pregnancy
Pregnancy, Animal
Progesterone - blood
Progesterone - immunology
Science
Science (multidisciplinary)
Time Factors
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Summary:Production of monoclonal antibodies by hybrid cell lines 1 provides a method potentially superior to conventional techniques for raising antisera 2 in respect of titre and specificity. Many lines have been prepared 3 that secrete antibody to cell-surface and soluble antigens and to viruses, but the products of hybridomas that recognize steroid haptens have not yet been exploited. Progesterone, the hormone of pregnancy, is essential for the establishment and maintenance of gestation in all mammalian species so far studied in detail 4 , and we describe here the production and characterization of an anti-progesterone monoclonal antibody which blocks the establishment of pregnancy in mice.
ISSN:0028-0836
1476-4687
DOI:10.1038/295415a0