Effects of milk and milk products on rectal mucosal cell proliferation in humans

Intake of dairy products and major dairy constituents (e.g., calcium) has been proposed to reduce the risk of colorectal cancer, although epidemiological studies have yielded inconclusive results. We conducted a randomized cross-over trial to test the effects of high- and low-dairy consumption diets...

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Bibliographic Details
Published in:Cancer epidemiology, biomarkers & prevention biomarkers & prevention, 1998-09, Vol.7 (9), p.757-766
Main Authors: Karagas, M R, Tosteson, T D, Greenberg, E R, Rothstein, R I, Roebuck, B D, Herrin, M, Ahnen, D
Format: Article
Language:English
Subjects:
Adult
Aged
Animals
Cell Division - drug effects
Cross-Over Studies
Dairy Products - adverse effects
Diet - adverse effects
Double-Blind Method
Female
Humans
Intestinal Mucosa - drug effects
Intestinal Mucosa - pathology
Male
Middle Aged
Milk - adverse effects
Rectum - drug effects
Rectum - pathology
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Summary:Intake of dairy products and major dairy constituents (e.g., calcium) has been proposed to reduce the risk of colorectal cancer, although epidemiological studies have yielded inconclusive results. We conducted a randomized cross-over trial to test the effects of high- and low-dairy consumption diets on rectal mucosal proliferation, a possible intermediary marker for large bowel cancer. From a gastroenterology clinic at an academic medical center, we recruited 40 patients, ages 25-79 years, who had either a history of a large bowel adenoma or a first-degree relative with large bowel cancer. Participants completed a baseline questionnaire covering demographic characteristics, health history, and habits and a food frequency questionnaire. They were randomized to a 12-week diet of either high dairy intake (six dairy servings/day) or low dairy intake (
ISSN:1055-9965
1538-7755