SPINAL ANALGESIA WITH HYPERBARIC BUPIVACAINE: EFFECTS OF VOLUME OF SOLUTION

The effects of 0.5% bupivacaine 1.5, 2 and 3ml in 8% glucose were compared in a double-blind study involving 30 patients undergoing spinal analgesia. The time to the onset of maximum segmental spread of analgesia was approximately 15 min for all three volumes. Cephalad spread of analgesia was relate...

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Bibliographic Details
Published in:British journal of anaesthesia : BJA 1982-01, Vol.54 (1), p.69-74
Main Authors: SUNDNES, K.O., VAAGENES, P., SKRETTING, P., LIND, B., EDSTRÓM, H.H.
Format: Article
Language:English
Subjects:
Aged
Anesthesia, Spinal
Bupivacaine - administration & dosage
Bupivacaine - pharmacology
Clinical Trials as Topic
Double-Blind Method
Female
Hemodynamics - drug effects
Humans
Male
Pressure
Time Factors
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Summary:The effects of 0.5% bupivacaine 1.5, 2 and 3ml in 8% glucose were compared in a double-blind study involving 30 patients undergoing spinal analgesia. The time to the onset of maximum segmental spread of analgesia was approximately 15 min for all three volumes. Cephalad spread of analgesia was related to the volume used: 1 5 ml reached T10, 2 ml T8 and 3 ml T7. The duration of analgesia increased with increasing volume, 3 ml producing analgesia in T8–T12 for 1.5–2 h, and in the lumbar region for 2.5–3 h. Increasing the volume increased the extent of motor blockade and speeded up its onset. Significant decreases in arterial pressure were observed in the 2- and 3-m] groups The changes in heart rate were moderate and not correlated with the amount of drug. Spinal headache occurred in two patients.
ISSN:0007-0912
1471-6771
DOI:10.1093/bja/54.1.69