The effect of diabetes mellitus on histopathological changes in the tissues under denture base and without mechanical pressure

Histopathological changes in the tissues under a denture base were studied with respect to the difference between diabetic and normal rats. Diabetes mellitus was induced in Wistar rats by streptozotocin. The experimental denture base was designed to make contact with the palatal mucosa without any c...

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Bibliographic Details
Published in:Journal of oral rehabilitation 1998-09, Vol.25 (9), p.715-720
Main Authors: Shirai, H., Sato, T., Hara, T., Minagi, S.
Format: Article
Language:English
Subjects:
Acrylic Resins
Animals
Bone Resorption - etiology
Cell Division
Dentistry
Denture Bases
Denture Design
Diabetes Mellitus, Experimental - pathology
Epithelium - pathology
Follow-Up Studies
Gold Alloys
Male
Maxillary Diseases - etiology
Mouth Mucosa - pathology
Oral Hygiene
Palate - pathology
Rats
Rats, Wistar
Stomatitis, Denture - etiology
Streptozocin
Stress, Mechanical
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Summary:Histopathological changes in the tissues under a denture base were studied with respect to the difference between diabetic and normal rats. Diabetes mellitus was induced in Wistar rats by streptozotocin. The experimental denture base was designed to make contact with the palatal mucosa without any continuous nor masticatory pressure. Histopathological observation periods were 1, 2, 4, 8, 12 and 20 weeks after the insertion of the denture base. Histopathological examination revealed that only the transient slight proliferative reaction observed in mucosal epithelium under a denture base in normal non‐diabetic rats, was lessened by induced diabetes mellitus. Moreover, covering the palatal mucosa with a denture base without any continuous nor masticatory pressure and with the maintenance of mucosal cleanliness under it and of the denture itself, did not cause any inflammatory change or bone resorption in the tissues under the base.
ISSN:0305-182X
1365-2842
DOI:10.1046/j.1365-2842.1998.00301.x