Chromosome analyses in man in the course of chemoprophylaxis against tuberculosis and of antituberculosis chemotherapy with isoniazid

Cytogenetic analyses were carried out in lymphocytes of 37 persons before and during a primary chemoprophylaxis or a preventive chemotherapy with isoniazid as well as of 30 patients suffering from active pulmonary tuberculosis before and during a chemotherapy with isoniazid in combination with two o...

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Bibliographic Details
Published in:Human genetics 1978-05, Vol.42 (1), p.31-43
Main Authors: Bauchinger, M, Gebhart, E, Fonatsch, C, Schmid, E, Müller, W, Obe, G, Beek, B, Göbel, D, Radenbach, K L
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Child
Child, Preschool
Chromosome Aberrations
Chromosomes - drug effects
Female
Humans
Isoniazid - pharmacology
Isoniazid - therapeutic use
Karyotyping
Lymphocytes
Male
Middle Aged
Tuberculosis, Pulmonary - drug therapy
Tuberculosis, Pulmonary - prevention & control
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Summary:Cytogenetic analyses were carried out in lymphocytes of 37 persons before and during a primary chemoprophylaxis or a preventive chemotherapy with isoniazid as well as of 30 patients suffering from active pulmonary tuberculosis before and during a chemotherapy with isoniazid in combination with two other antimycobacterial drugs. The results of the four participating research groups consistently reveal no indication for a chromosome damaging activity of isoniazid, of its metabolites in the human organism and of the administered drug regimens.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00291621