Leukemic reticuloendotheliosis. Report of a case with peripheral blood remission on androgen therapy

Leukemic reticuloendotheliosis (LRE) has been generally considered to be poorly responsive to therapy other than splenectomy. The patient presented below developed a complete peripheral blood remission after prolonged therapy with an androgen (oxymetholone). There is very little published experience...

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Bibliographic Details
Published in:Cancer 1978-05, Vol.41 (5), p.1964-1966
Main Authors: Lusch, Charles J., Ramsey, Harry E., Katayama, Isao
Format: Article
Language:English
Subjects:
Adult
Antineoplastic Agents - therapeutic use
Blood Cell Count
Blood Platelets
Hematocrit
Humans
Leukemia, Hairy Cell - blood
Leukemia, Hairy Cell - drug therapy
Leukemia, Hairy Cell - surgery
Male
Oxymetholone - therapeutic use
Remission, Spontaneous
Splenectomy
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Summary:Leukemic reticuloendotheliosis (LRE) has been generally considered to be poorly responsive to therapy other than splenectomy. The patient presented below developed a complete peripheral blood remission after prolonged therapy with an androgen (oxymetholone). There is very little published experience with androgen therapy in LRE. The experience with this patient suggests that androgens may produce a clinical remission by inducing significant improvement in the peripheral blood in some patients with this disease.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(197805)41:5<1964::AID-CNCR2820410541>3.0.CO;2-J