The bactericidal activity of nitrofurantoin and metronidazole against anaerobic bacteria

The time-related bactericidal effects of metronidazole and nitrofurantoin were studied in two strains of Bacteroides fragilis and Clostridium perfringens. At concentrations of approximately 5 times the MICs, metronidazole and nitrofurantoin demonstrated a similar rapid cidal effect. The bactericidal...

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Bibliographic Details
Published in:Journal of antimicrobial chemotherapy 1978-03, Vol.4 (2), p.177-184
Main Author: Ralph, E D
Format: Article
Language:English
Subjects:
Bacteroides fragilis - drug effects
Clostridium perfringens - drug effects
Drug Combinations
Hydrogen-Ion Concentration
Metronidazole - pharmacology
Microbial Sensitivity Tests
Nitrofurantoin - pharmacology
Time Factors
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Summary:The time-related bactericidal effects of metronidazole and nitrofurantoin were studied in two strains of Bacteroides fragilis and Clostridium perfringens. At concentrations of approximately 5 times the MICs, metronidazole and nitrofurantoin demonstrated a similar rapid cidal effect. The bactericidal activity of both drugs against a strain of B. fragilis was not significantly affected over a pH range of 5.5 to 8.0, varying the inoculum size of the organism between 106 to 107 c.f.u./ml, or by the growth phase of the organism. The rate of bactericidal activity varied with the concentration of nitrofurantoin and metronidazole, and an additive effect against B. fragilis was noted when the drugs were used in combination. The cidal activity of both drugs was associated with their inactivation in the medium.
ISSN:0305-7453
1460-2091
DOI:10.1093/jac/4.2.177