Cytochrome c oxidase as the receptor molecule for chemoaccumulation (chemotaxis) of Euglena toward oxygen

Chemoaccumulation of Euglena gracilis toward oxygen was selectively inhibited, without concomitant effects on cell motility, by cyanide (10$^{-6}$ to 10$^{-4}$ molar) and carbon monoxide (5 × 10$^{-5}$ to 5 × 10$^{-4}$ molar). Above these concentrations, motility of the cell was impaired and the che...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) 1978-05, Vol.200 (4341), p.548-544
Main Authors: Miller, S, Diehn, B
Format: Article
Language:English
Subjects:
Algae
Animals
Azides
Azides - pharmacology
Carbon monoxide
Carbon Monoxide - pharmacology
chemotaxis
Chemotaxis - drug effects
Cyanides
Cyanides - pharmacology
Cytochromes
Cytochromes - antagonists & inhibitors
Electron Transport Complex IV - antagonists & inhibitors
Electron Transport Complex IV - physiology
Euglena
Euglena gracilis - physiology
Oxidases
Oxygen
Pathology
Receptors
Receptors, Drug - physiology
Sodium
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Summary:Chemoaccumulation of Euglena gracilis toward oxygen was selectively inhibited, without concomitant effects on cell motility, by cyanide (10$^{-6}$ to 10$^{-4}$ molar) and carbon monoxide (5 × 10$^{-5}$ to 5 × 10$^{-4}$ molar). Above these concentrations, motility of the cell was impaired and the chemosensory response was inhibited. Azide did not affect chemoaccumulation even at 5 × 10$^{-3}$ molar. It is concluded that cytochrome a$_{3}$ serves as the chemoreceptor molecule for oxygen-mediated behavioral responses in Euglena.
ISSN:0036-8075
1095-9203
DOI:10.1126/science.205948