Whole bone marrow irradiation for the treatment of multiple myeloma

Nine patients with muliple myeloma were treated with whole bone marrow irradiation. Six had heavily pretreated disease refractory to chemotherapy. Three had stable disease lightly pretreated by chemotherapy. A modification of the “three and two” total nodal radiation technique was employed. Although...

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Bibliographic Details
Published in:Cancer 1982-04, Vol.49 (7), p.1328-1333
Main Authors: Coleman, Morton, Saletan, Stephen, Wolf, David, Nisce, Lourdes, Wasser, Jeffrey, McIntyre, O. Ross, Tulloh, Marchant
Format: Article
Language:English
Subjects:
Adult
Aged
Bence Jones Protein - blood
Bone Marrow - radiation effects
Female
Humans
Immunoglobulin A - analysis
Immunoglobulin G - analysis
Leukocyte Count
Male
Middle Aged
Multiple Myeloma - drug therapy
Multiple Myeloma - radiotherapy
Platelet Count
Whole-Body Irradiation
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Summary:Nine patients with muliple myeloma were treated with whole bone marrow irradiation. Six had heavily pretreated disease refractory to chemotherapy. Three had stable disease lightly pretreated by chemotherapy. A modification of the “three and two” total nodal radiation technique was employed. Although varying and often severe treatment related cytopenia occurred, infectious complications, clinical bleeding, and nonhematalogic complications were minimal. Five of nine patients showed a decrease in monoclonal protein components, and one showed an increase during treatment. These preliminary results indicate that a reduction of tumor cell burden may occur in patients following whole bone marrow irradiation and that the technique is feasible. Whole bone marrow irradiation combined with chemotherapy represents a new conceptual therapeutic approach for multiple myeloma.
ISSN:0008-543X
1097-0142
DOI:10.1002/1097-0142(19820401)49:7<1328::AID-CNCR2820490703>3.0.CO;2-4