Loading…

Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)

Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cel...

Full description

Saved in:

Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Ill.), 1982-03, Vol.42 (3), p.791-798
Main Authors:	Wheeler, G P, Bowdon, B J, Werline, J A, Adamson, D J, Temple, Jr, C G
Format:	Article
Language:	English
Subjects:	Animals Antineoplastic Agents - pharmacology Cell Division - drug effects Cell Line Cell Survival - drug effects DNA - biosynthesis Dose-Response Relationship, Drug Drug Evaluation, Preclinical Methotrexate - pharmacology Mice Mice, Inbred BALB C Mitosis - drug effects Neoplasm Transplantation Neoplasms, Experimental - pathology Pyrazines - pharmacology
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

cited_by
cites
container_end_page	798
container_issue	3
container_start_page	791
container_title	Cancer research (Chicago, Ill.)
container_volume	42
creator	Wheeler, G P Bowdon, B J Werline, J A Adamson, D J Temple, Jr, C G
description	Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.
format	article
fullrecord	<record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_74000840</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>74000840</sourcerecordid><originalsourceid>FETCH-LOGICAL-h238t-11eb8291ba67837334287b185d0d0457bdfdf271c766d7ff561c2dd3770470663</originalsourceid><addsrcrecordid>eNotkF1LwzAUhnuhzDn9CUKuZMIC-Wia9FKGH4MxL9SrMUrSpDbSJrXJxPq__H9Wt4vD4eF9OBzek2SKEBKQpZycJechvI_IMGKTZMIRy3POp8nPytVW2Wi9A74CrY0-2ACk0-NEW0pXmh7IMtpPGwcg36R1IQLz1ZnetsZF2QBnfNfI0AagBmBiPTSAQdla5yFeEKhtPejeQwq38w1s_wXpbDPmNwfawW7orfZbukih2o0gv62DHA5NKXslWxkNmG-elwALnBNxc5GcVrIJ5vK4Z8nr_d3L8hGunx5Wy9s1rAkVEWJslCA5VjLjgnJKUyK4woJppFHKuNKVrgjHJc8yzauKZbgkWlPOUcpRltFZcn242_X-Y29CLFobStOM_xu_DwVP_xpO0SheHcW9ao0uurEc2Q_FsWf6CyGweU8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>74000840</pqid></control><display><type>article</type><title>Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)</title><source>EZB Electronic Journals Library</source><creator>Wheeler, G P ; Bowdon, B J ; Werline, J A ; Adamson, D J ; Temple, Jr, C G</creator><creatorcontrib>Wheeler, G P ; Bowdon, B J ; Werline, J A ; Adamson, D J ; Temple, Jr, C G</creatorcontrib><description>Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.</description><identifier>ISSN: 0008-5472</identifier><identifier>PMID: 7059977</identifier><language>eng</language><publisher>United States</publisher><subject>Animals ; Antineoplastic Agents - pharmacology ; Cell Division - drug effects ; Cell Line ; Cell Survival - drug effects ; DNA - biosynthesis ; Dose-Response Relationship, Drug ; Drug Evaluation, Preclinical ; Methotrexate - pharmacology ; Mice ; Mice, Inbred BALB C ; Mitosis - drug effects ; Neoplasm Transplantation ; Neoplasms, Experimental - pathology ; Pyrazines - pharmacology</subject><ispartof>Cancer research (Chicago, Ill.), 1982-03, Vol.42 (3), p.791-798</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/7059977$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wheeler, G P</creatorcontrib><creatorcontrib>Bowdon, B J</creatorcontrib><creatorcontrib>Werline, J A</creatorcontrib><creatorcontrib>Adamson, D J</creatorcontrib><creatorcontrib>Temple, Jr, C G</creatorcontrib><title>Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)</title><title>Cancer research (Chicago, Ill.)</title><addtitle>Cancer Res</addtitle><description>Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.</description><subject>Animals</subject><subject>Antineoplastic Agents - pharmacology</subject><subject>Cell Division - drug effects</subject><subject>Cell Line</subject><subject>Cell Survival - drug effects</subject><subject>DNA - biosynthesis</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Evaluation, Preclinical</subject><subject>Methotrexate - pharmacology</subject><subject>Mice</subject><subject>Mice, Inbred BALB C</subject><subject>Mitosis - drug effects</subject><subject>Neoplasm Transplantation</subject><subject>Neoplasms, Experimental - pathology</subject><subject>Pyrazines - pharmacology</subject><issn>0008-5472</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNotkF1LwzAUhnuhzDn9CUKuZMIC-Wia9FKGH4MxL9SrMUrSpDbSJrXJxPq__H9Wt4vD4eF9OBzek2SKEBKQpZycJechvI_IMGKTZMIRy3POp8nPytVW2Wi9A74CrY0-2ACk0-NEW0pXmh7IMtpPGwcg36R1IQLz1ZnetsZF2QBnfNfI0AagBmBiPTSAQdla5yFeEKhtPejeQwq38w1s_wXpbDPmNwfawW7orfZbukih2o0gv62DHA5NKXslWxkNmG-elwALnBNxc5GcVrIJ5vK4Z8nr_d3L8hGunx5Wy9s1rAkVEWJslCA5VjLjgnJKUyK4woJppFHKuNKVrgjHJc8yzauKZbgkWlPOUcpRltFZcn242_X-Y29CLFobStOM_xu_DwVP_xpO0SheHcW9ao0uurEc2Q_FsWf6CyGweU8</recordid><startdate>19820301</startdate><enddate>19820301</enddate><creator>Wheeler, G P</creator><creator>Bowdon, B J</creator><creator>Werline, J A</creator><creator>Adamson, D J</creator><creator>Temple, Jr, C G</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>19820301</creationdate><title>Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)</title><author>Wheeler, G P ; Bowdon, B J ; Werline, J A ; Adamson, D J ; Temple, Jr, C G</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-h238t-11eb8291ba67837334287b185d0d0457bdfdf271c766d7ff561c2dd3770470663</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Animals</topic><topic>Antineoplastic Agents - pharmacology</topic><topic>Cell Division - drug effects</topic><topic>Cell Line</topic><topic>Cell Survival - drug effects</topic><topic>DNA - biosynthesis</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Evaluation, Preclinical</topic><topic>Methotrexate - pharmacology</topic><topic>Mice</topic><topic>Mice, Inbred BALB C</topic><topic>Mitosis - drug effects</topic><topic>Neoplasm Transplantation</topic><topic>Neoplasms, Experimental - pathology</topic><topic>Pyrazines - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wheeler, G P</creatorcontrib><creatorcontrib>Bowdon, B J</creatorcontrib><creatorcontrib>Werline, J A</creatorcontrib><creatorcontrib>Adamson, D J</creatorcontrib><creatorcontrib>Temple, Jr, C G</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Cancer research (Chicago, Ill.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wheeler, G P</au><au>Bowdon, B J</au><au>Werline, J A</au><au>Adamson, D J</au><au>Temple, Jr, C G</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)</atitle><jtitle>Cancer research (Chicago, Ill.)</jtitle><addtitle>Cancer Res</addtitle><date>1982-03-01</date><risdate>1982</risdate><volume>42</volume><issue>3</issue><spage>791</spage><epage>798</epage><pages>791-798</pages><issn>0008-5472</issn><abstract>Ethyl 5-amino-1,2-dihydro-3-[N-methylanilino)methyl]pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928) is reported to be active against several experimental neoplasms. The experimental data obtained in the present study indicate that it causes the accumulation of cells at mitosis with both cultured cells and ascites cancer cells in vivo. This effect was observed with L1210, P388, colon cancer 26, colon cancer 38, and H.Ep. 2 cells in culture and with L1210 cells and P388 cells in mice. The agent was also active in vitro and in vivo against a line of leukemia P388 cells that are resistant to vincristine.</abstract><cop>United States</cop><pmid>7059977</pmid><tpages>8</tpages></addata></record>
fulltext	fulltext
identifier	ISSN: 0008-5472
ispartof	Cancer research (Chicago, Ill.), 1982-03, Vol.42 (3), p.791-798
issn	0008-5472
language	eng
recordid	cdi_proquest_miscellaneous_74000840
source	EZB Electronic Journals Library
subjects	Animals Antineoplastic Agents - pharmacology Cell Division - drug effects Cell Line Cell Survival - drug effects DNA - biosynthesis Dose-Response Relationship, Drug Drug Evaluation, Preclinical Methotrexate - pharmacology Mice Mice, Inbred BALB C Mitosis - drug effects Neoplasm Transplantation Neoplasms, Experimental - pathology Pyrazines - pharmacology
title	Inhibition of mitosis and anticancer activity against experimental neoplasms by ethyl 5-amino-1,2-dihydro-3-[(N-methylanilino)methyl]-pyrido[3,4-b]pyrazin-7-ylcarbamate (NSC 181928)
url	http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-05T12%3A14%3A45IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Inhibition%20of%20mitosis%20and%20anticancer%20activity%20against%20experimental%20neoplasms%20by%20ethyl%205-amino-1,2-dihydro-3-%5B(N-methylanilino)methyl%5D-pyrido%5B3,4-b%5Dpyrazin-7-ylcarbamate%20(NSC%20181928)&rft.jtitle=Cancer%20research%20(Chicago,%20Ill.)&rft.au=Wheeler,%20G%20P&rft.date=1982-03-01&rft.volume=42&rft.issue=3&rft.spage=791&rft.epage=798&rft.pages=791-798&rft.issn=0008-5472&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E74000840%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-h238t-11eb8291ba67837334287b185d0d0457bdfdf271c766d7ff561c2dd3770470663%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=74000840&rft_id=info:pmid/7059977&rfr_iscdi=true