Effect of aminoglycosides on proximal tubular membranes of the human kidney

The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/...

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Bibliographic Details
Published in:European journal of clinical pharmacology 1978-05, Vol.13 (2), p.133-142
Main Authors: Mondorf, A W, Breier, J, Hendus, J, Scherberich, J E, Mackenrodt, G, Shah, P M, Stille, W, Schoeppe, W
Format: Article
Language:English
Subjects:
Adolescent
Adult
Alanine Transaminase - blood
Aminoglycosides - pharmacology
Aminoglycosides - urine
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - urine
Diuretics
Enzymes - urine
Female
Humans
Kidney Tubules, Proximal - drug effects
Male
Membranes - drug effects
Middle Aged
Sex Factors
Time Factors
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Summary:The effect of the aminoglycosides amikacin, gentamicin, netilmicin sisomicin and tobramycin on the proximal tubule of the human kidney was investigated in 78 healthy subjects. Fifteen adults were each given gentamicin, sisomicin or tobramycin 3 mg/kg bodyweight, 10 subjects received netilmicin 3 mg/kg or amikacin 15 mg/kg additionally seven subjects amikacin 10 mg and six subjects netilmicin 6 mg on three consecutive days. The principal enzyme of the brush border membrane of the proximal tubule, alanine aminopeptidase (AAP), was determined enzymatically and immunologically in 24-hour urines. The effects of the various aminoglycosides on the membranes were different. Less of membrane AAP was greatest after amikacin and was least after tobramycin. There was no difference between gentamicin, netilmicin, and sisomicin, which had an effect intermediate between the other two compounds. The elimination of AAP occurred at intervals which might possibly have been caused by impairment of cell cycles.
ISSN:0031-6970
1432-1041
DOI:10.1007/BF00609758