Attempts to establish infections with Strongyloides stercoralis in mice and other laboratory animals

Infection of a dog with Strongyloides stercoralis filariform larvae resulted in a persistent infection. Patent infections were not seen in rabbits, guinea-pigs, rats and 11 inbred strains and one outbred strain of mice. Manipulation of factors known to influence S. ratti infections in mice, such as...

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Bibliographic Details
Published in:Journal of helminthology 1982-03, Vol.56 (1), p.23-26
Main Authors: Dawkins, H. J. S., Grove, D. I.
Format: Article
Language:English
Subjects:
Age Factors
Animals
Dogs
Female
Guinea Pigs
Immunity, Innate
Intestines - parasitology
Male
Mice
Mice, Inbred Strains
Muscles - parasitology
Prednisolone - pharmacology
Rabbits
Rats
Rats, Inbred Strains
Research Papers
Sex Factors
Skin - parasitology
Strongyloides - physiology
Strongyloides stercoralis
Strongyloidiasis - immunology
T-Lymphocytes - immunology
Technique, Experimental hosts
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Summary:Infection of a dog with Strongyloides stercoralis filariform larvae resulted in a persistent infection. Patent infections were not seen in rabbits, guinea-pigs, rats and 11 inbred strains and one outbred strain of mice. Manipulation of factors known to influence S. ratti infections in mice, such as age and sex of the host and the route of larval presentation, did not facilitate the appearance of rhabditiform larvae in the stools. Administration of immunosuppressive doses of corticosterioids to rabbits, guinea-pigs and C57B1/6 mice did not permit complete development. Similarly, the course of infection was not altered in T cell-deficient hypothymic (nu/nu) mice. The fate of filariform larvae applied to the skin of mice was ascertained; filariform larvae were observed to migrate from the skin via the lungs to the muscles within several days of infection. Although S. stercoralis does not develop to maturity in the small intestine of mice, this system does allow in vivo studies of the actions of anthelmintics against filariform larvae as well as a number of aspects of the immune response to this parasite.
ISSN:0022-149X
1475-2697
DOI:10.1017/S0022149X00034957