Metabolism and Excretion of Normorphine in Dogs

Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One p...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1978-06, Vol.67 (6), p.878-880
Main Authors: Yeh, S.Y., McQuinn, R.L., Krebs, H.A., Gorodetzky, C.W.
Format: Article
Language:English
Subjects:
Animals
Chromatography, Gas
Dealkylation
Dogs
Excretion-normorphine in dogs
Feces - analysis
Female
Mass Spectrometry
metabolism and excretion in dogs
Metabolism-normorphine in dogs
Morphine Derivatives - metabolism
Morphine Derivatives - urine
Narcotic analgesics-normorphine
Narcotic analgesics—normorphine, metabolism and excretion in Dogs
Normorphine-metabolism and excretion in dogs
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Summary:Normorphine metabolism was studied in dogs given 20 mg of normorphine hydrochloride/kg sc. Free and conjugated normorphine excreted in the urine over 144 hr represented 32 and 32%, respectively, of the administered dose. Eighty percent of the urinary excretion of the drug occurred within 9 hr. One percent of the administered dose was excreted as free normorphine in the feces. The urine was chromatographed on a column. Evaporation of the washing and methanolic effluent yielded a residue, which was purified by crystallization from aqueous methanol. Results of UV and IR studies, elemental analysis, and determination of normorphine and glucuronic acid content established the identity of this metabolite as normorphine 3-glucuronide. Dihydronormorphine and dehydronormorphine were detected with GLC–mass spectrometry as minor metabolites.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600670646