Unscheduled DNA-synthesis in UV-irradiated spleen lymphocytes of the rat after whole-body X-irradiation

Unscheduled DNA-synthesis of UV-irradiated spleen lymphocytes of the rat is inhibited in a dose-dependent manner by total-body X-irradiation. The reaction is observed immediately after exposure and reaches its maximum within 8--16 h. Doses of some rads are detectable. Following sublethal X-irradiati...

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Bibliographic Details
Published in:Radiation and environmental biophysics 1978-03, Vol.15 (1), p.77-83
Main Authors: Hollatz, R, Tempel, K
Format: Article
Language:English
Subjects:
Animals
DNA Repair - radiation effects
Lymphocytes - radiation effects
Male
Rats
Spleen - radiation effects
Ultraviolet Rays
X-Rays
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Summary:Unscheduled DNA-synthesis of UV-irradiated spleen lymphocytes of the rat is inhibited in a dose-dependent manner by total-body X-irradiation. The reaction is observed immediately after exposure and reaches its maximum within 8--16 h. Doses of some rads are detectable. Following sublethal X-irradiation (250 rad), regeneration takes 4--6 weeks. Analogous results have been obtained in rats treated with 2,4,6-triethyleneimino-1,3,5-triazine. Regardless of the action mechanisms, it is concluded from the present results that the inhibition of the unscheduled incorporation of thymidine-3H in splenic lymphocytes is a very sensitive, though not specific expression of impairment of the lymphatic system.
ISSN:0301-634X
1432-2099
DOI:10.1007/BF01330901