Therapeutic Effects of Foscarnet Sodium and Acyclovir on Cutaneous Infections Due to Herpes Simplex Virus Type 1 in Guinea Pigs

The therapeutic effects of topically applied foscarnet sodium and acyclovir on cutaneous infections due to herpes simplexvirus type 1(HSV-1) were studied in guinea pigs. Foscarnet cream (3%) reduced both the cumulative vesicle score and the time for healing when HSV-1 strains C42 and 79 were tested....

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Published in:The Journal of infectious diseases 1982-04, Vol.145 (4), p.569-573
Main Authors: Alenius, S., Berg, M., Broberg, F., Eklind, K., Lindborg, B., Öberg, B.
Format: Article
Language:English
Subjects:
Acyclovir
Administration, Topical
Animals
Cream
Dose-Response Relationship, Drug
Foscarnet
Glycols
Guanine - administration & dosage
Guanine - analogs & derivatives
Guanine - therapeutic use
Guinea Pigs
Herpes Simplex - drug therapy
herpes simplex virus 1
Human herpesvirus 1
Infections
Lesions
Medical treatment
Ointments
Organophosphorus Compounds - therapeutic use
Phosphonoacetic Acid - administration & dosage
Phosphonoacetic Acid - analogs & derivatives
Phosphonoacetic Acid - therapeutic use
Polyethylenes
Simplexvirus - growth & development
Skin Diseases - drug therapy
Sodium
Therapeutics
Viruses
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container_end_page 573
container_issue 4
container_start_page 569
container_title The Journal of infectious diseases
container_volume 145
creator Alenius, S.
Berg, M.
Broberg, F.
Eklind, K.
Lindborg, B.
Öberg, B.
description The therapeutic effects of topically applied foscarnet sodium and acyclovir on cutaneous infections due to herpes simplexvirus type 1(HSV-1) were studied in guinea pigs. Foscarnet cream (3%) reduced both the cumulative vesicle score and the time for healing when HSV-1 strains C42 and 79 were tested. The application of foscarnet in cream form resulted in a dose-dependent reduction in skin virus titers and vesicle scores at concentrations ranging from 0.05% to 3%. Infections due to HSV-1 strain 79, but not those due to strain C42, were sensitive to treatment with 5% acyclovir in polyethylene glycolointment. Topical application of 3% acyclovirin dimethyl sulfoxide on infections due to HSV-1 strain C42 resulted in a reduction in the skin virus titers, lesion scores, and the time for healing. Acyclovir, in both polyethylene glycoland dimethyl sulfoxide, was consistently less active than foscarnet cream in these animal experiments.
doi_str_mv 10.1093/infdis/145.4.569
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Foscarnet cream (3%) reduced both the cumulative vesicle score and the time for healing when HSV-1 strains C42 and 79 were tested. The application of foscarnet in cream form resulted in a dose-dependent reduction in skin virus titers and vesicle scores at concentrations ranging from 0.05% to 3%. Infections due to HSV-1 strain 79, but not those due to strain C42, were sensitive to treatment with 5% acyclovir in polyethylene glycolointment. Topical application of 3% acyclovirin dimethyl sulfoxide on infections due to HSV-1 strain C42 resulted in a reduction in the skin virus titers, lesion scores, and the time for healing. 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1537-6613
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source JSTOR Archival Journals and Primary Sources Collection; Oxford University Press Archive
subjects Acyclovir
Administration, Topical
Animals
Cream
Dose-Response Relationship, Drug
Foscarnet
Glycols
Guanine - administration & dosage
Guanine - analogs & derivatives
Guanine - therapeutic use
Guinea Pigs
Herpes Simplex - drug therapy
herpes simplex virus 1
Human herpesvirus 1
Infections
Lesions
Medical treatment
Ointments
Organophosphorus Compounds - therapeutic use
Phosphonoacetic Acid - administration & dosage
Phosphonoacetic Acid - analogs & derivatives
Phosphonoacetic Acid - therapeutic use
Polyethylenes
Simplexvirus - growth & development
Skin Diseases - drug therapy
Sodium
Therapeutics
Viruses
title Therapeutic Effects of Foscarnet Sodium and Acyclovir on Cutaneous Infections Due to Herpes Simplex Virus Type 1 in Guinea Pigs
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