Biosynthetic relationships of big and little gastrins

ACCUMULATING evidence suggests that many peptide hormones are synthesised initially as part of larger precursor molecules 1 . There is also evidence that several different peptides, for example, corticotrophin, β lipotrophin, the melanotrophins and the endorphins may arise from a single precursor mo...

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Bibliographic Details
Published in:Nature (London) 1978-06, Vol.273 (5665), p.770-772
Main Authors: DOCKRAY, G. J, VAILLANT, CAMILLE, HOPKINS, C. R
Format: Article
Language:English
Subjects:
Animals
Antibody Specificity
Fluorescent Antibody Technique
Gastric Mucosa - metabolism
Gastrins - biosynthesis
Gastrins - immunology
Humanities and Social Sciences
letter
Molecular Weight
multidisciplinary
Protein Precursors - metabolism
Science
Science (multidisciplinary)
Swine
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Summary:ACCUMULATING evidence suggests that many peptide hormones are synthesised initially as part of larger precursor molecules 1 . There is also evidence that several different peptides, for example, corticotrophin, β lipotrophin, the melanotrophins and the endorphins may arise from a single precursor molecule which is processed differently in different secretory systems 2 . The post-translational processing of large precursors would therefore seem to play a regulatory role in determining the biological activity of the final secretory product. We have examined the relationships between the principal biologically active forms of the hormone gastrin in porcine antral mucosa.
ISSN:0028-0836
1476-4687
DOI:10.1038/273770a0