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beta 2-Microglobulin and its relationship to the immune system

beta 2-Microglobulin has been isolated from several species, but only bovine beta 2-microglobulin, previously known as lactollin, has been crystallized. An improved method for its isolation from colostrum is described. The bovine homologue exhibits a concentration-dependent aggregation behavior. bet...

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Published in:	Journal of dairy science 1982-02, Vol.65 (2), p.317-325
Main Authors:	Groves, M L, Greenberg, R
Format:	Article
Language:	English
Subjects:	Amino Acid Sequence Animals beta 2-Microglobulin - analysis beta 2-Microglobulin - biosynthesis beta 2-Microglobulin - immunology Beta-Globulins - immunology Cattle Colostrum - immunology Histocompatibility Antigens - analysis HLA Antigens - analysis Humans Milk - immunology
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container_issue	2
container_start_page	317
container_title	Journal of dairy science
container_volume	65
creator	Groves, M L Greenberg, R
description	beta 2-Microglobulin has been isolated from several species, but only bovine beta 2-microglobulin, previously known as lactollin, has been crystallized. An improved method for its isolation from colostrum is described. The bovine homologue exhibits a concentration-dependent aggregation behavior. beta 2-Microglobulin is related to both immune and histocompatibility antigen systems. It exhibits homology with the constant domains of the immunoglobulin-G light and heavy chains and is an integral part of histocompatibility antigens bound to cell surface. beta 2-Microglobulin also occurs in the free state in various body fluids including milk and colostrum. The possible relationship of elevated free beta 2-microglobulin of pathological conditions is suggested for future research.
doi_str_mv	10.3168/jds.S0022-0302(82)82193-0
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The possible relationship of elevated free beta 2-microglobulin of pathological conditions is suggested for future research.</description><identifier>ISSN: 0022-0302</identifier><identifier>DOI: 10.3168/jds.S0022-0302(82)82193-0</identifier><identifier>PMID: 6176605</identifier><language>eng</language><publisher>United States</publisher><subject>Amino Acid Sequence ; Animals ; beta 2-Microglobulin - analysis ; beta 2-Microglobulin - biosynthesis ; beta 2-Microglobulin - immunology ; Beta-Globulins - immunology ; Cattle ; Colostrum - immunology ; Histocompatibility Antigens - analysis ; HLA Antigens - analysis ; Humans ; Milk - immunology</subject><ispartof>Journal of dairy science, 1982-02, Vol.65 (2), p.317-325</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27922,27923</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/6176605$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Groves, M L</creatorcontrib><creatorcontrib>Greenberg, R</creatorcontrib><title>beta 2-Microglobulin and its relationship to the immune system</title><title>Journal of dairy science</title><addtitle>J Dairy Sci</addtitle><description>beta 2-Microglobulin has been isolated from several species, but only bovine beta 2-microglobulin, previously known as lactollin, has been crystallized. An improved method for its isolation from colostrum is described. The bovine homologue exhibits a concentration-dependent aggregation behavior. beta 2-Microglobulin is related to both immune and histocompatibility antigen systems. It exhibits homology with the constant domains of the immunoglobulin-G light and heavy chains and is an integral part of histocompatibility antigens bound to cell surface. beta 2-Microglobulin also occurs in the free state in various body fluids including milk and colostrum. The possible relationship of elevated free beta 2-microglobulin of pathological conditions is suggested for future research.</description><subject>Amino Acid Sequence</subject><subject>Animals</subject><subject>beta 2-Microglobulin - analysis</subject><subject>beta 2-Microglobulin - biosynthesis</subject><subject>beta 2-Microglobulin - immunology</subject><subject>Beta-Globulins - immunology</subject><subject>Cattle</subject><subject>Colostrum - immunology</subject><subject>Histocompatibility Antigens - analysis</subject><subject>HLA Antigens - analysis</subject><subject>Humans</subject><subject>Milk - immunology</subject><issn>0022-0302</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1982</creationdate><recordtype>article</recordtype><recordid>eNo9j89LwzAYhnNQ5pz-CUK8iB46v3xJ0_QiyJg_YOJBPZckTV1G29QmPey_d-Dw9PK8PLzwEnLNYMmZVPe7Oi4_ABAz4IC3Cu8UspJncELm__UZOY9xd0CGkM_ITLJCSsjn5MG4pClmb96O4bsNZmp9T3VfU58iHV2rkw993PqBpkDT1lHfdVPvaNzH5LoLctroNrrLYy7I19P6c_WSbd6fX1ePm2xAkCmTFlHYnAulSsasBcEAAawtZZ3nKjdcNYajFg2WTFttGzQlMwIcGBDC8AW5-dsdxvAzuZiqzkfr2lb3LkyxKgSgUIU6iFdHcTKdq6th9J0e99XxMP8FH1JW7g</recordid><startdate>198202</startdate><enddate>198202</enddate><creator>Groves, M L</creator><creator>Greenberg, R</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>198202</creationdate><title>beta 2-Microglobulin and its relationship to the immune system</title><author>Groves, M L ; Greenberg, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p206t-6c224c53488911cc0410200cc96d5585b38fb32a4f291acacf2b91b40e0b044b3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1982</creationdate><topic>Amino Acid Sequence</topic><topic>Animals</topic><topic>beta 2-Microglobulin - analysis</topic><topic>beta 2-Microglobulin - biosynthesis</topic><topic>beta 2-Microglobulin - immunology</topic><topic>Beta-Globulins - immunology</topic><topic>Cattle</topic><topic>Colostrum - immunology</topic><topic>Histocompatibility Antigens - analysis</topic><topic>HLA Antigens - analysis</topic><topic>Humans</topic><topic>Milk - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Groves, M L</creatorcontrib><creatorcontrib>Greenberg, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dairy science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Groves, M L</au><au>Greenberg, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>beta 2-Microglobulin and its relationship to the immune system</atitle><jtitle>Journal of dairy science</jtitle><addtitle>J Dairy Sci</addtitle><date>1982-02</date><risdate>1982</risdate><volume>65</volume><issue>2</issue><spage>317</spage><epage>325</epage><pages>317-325</pages><issn>0022-0302</issn><abstract>beta 2-Microglobulin has been isolated from several species, but only bovine beta 2-microglobulin, previously known as lactollin, has been crystallized. 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source	ScienceDirect (Online service); EZB Electronic Journals Library
subjects	Amino Acid Sequence Animals beta 2-Microglobulin - analysis beta 2-Microglobulin - biosynthesis beta 2-Microglobulin - immunology Beta-Globulins - immunology Cattle Colostrum - immunology Histocompatibility Antigens - analysis HLA Antigens - analysis Humans Milk - immunology
title	beta 2-Microglobulin and its relationship to the immune system
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