EM5400, A FAMILY OF MONOBACTAM ANTIBIOTICS PRODUCED BY AGROBACTERIUM RADIOBACTER: I. TAXONOMY, FERMENTATION AND BIOLOGICAL PROPERTIES

A series of novel monocyclic β-lactam antibiotics were isolated from a strain of Agrobacterium radiobacter. The compounds show weak antibacterial activity but are highly stable to hydrolysis by β-lactamases.

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Bibliographic Details
Published in:Journal of antibiotics 1982, Vol.35(3), pp.295-299
Main Authors: WELLS, J. SCOTT, TREJO, WILLIAM H., PRINCIPE, PACIFICO A., BUSH, KAREN, GEORGOPAPADAKOU, NAFSIKA, BONNER, DANIEL P., SYKES, RICHARD B.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - pharmacology
beta-Lactamase Inhibitors
beta-Lactams - biosynthesis
beta-Lactams - pharmacology
Carboxypeptidases - antagonists & inhibitors
Fermentation
Rhizobium - classification
Rhizobium - metabolism
Rhizobium - pathogenicity
Streptomyces - enzymology
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Description
Summary:A series of novel monocyclic β-lactam antibiotics were isolated from a strain of Agrobacterium radiobacter. The compounds show weak antibacterial activity but are highly stable to hydrolysis by β-lactamases.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.35.295