THE TOTAL SYNTHESIS OF NOCARDICIN A

We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.

Saved in:
Bibliographic Details
Published in:Journal of antibiotics 1982, Vol.35(3), pp.329-334
Main Authors: CURRAN, WILLIAM V., SASSIVER, MARTIN L., ROSS, ADMA S., FIELDS, THOMAS L., BOOTHE, JAMES H.
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - chemical synthesis
Anti-Bacterial Agents - pharmacology
Chemical Phenomena
Chemistry
Lactams - chemical synthesis
Lactams - pharmacology
Stereoisomerism
Citations: Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We report here a total synthesis of nocardicin A. The antibiotic was obtained as a mixture of diastereoisomers that possessed approximately one quarter of the antibacterial activity of the naturally occurring material.
ISSN:0021-8820
1881-1469
DOI:10.7164/antibiotics.35.329