Separation of Penicillin and Its Major Degradation Products by Ion-Pair Reversed-Phase High-Pressure Liquid Chromatography

An ion-pair reversed-phase high-pressure liquid chromatographic technique capable of separating penicillin and its major degradation products within 8 min was developed. The influence of pH, counterion concentration, buffer concentration, and organic modifier content was studied and the observed beh...

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Bibliographic Details
Published in:Journal of pharmaceutical sciences 1982-03, Vol.71 (3), p.351-353
Main Authors: Ghebre-Sellassie, Isaac, Hem, Stanley L., Knevel, Adelbert M.
Format: Article
Language:English
Subjects:
Chemical Phenomena
Chemistry
Chromatography, High Pressure Liquid - methods
Degradation products-penicillin
Degradation products—penicillin, separation by ion-pair reversed-phase high-pressure liquid chromatography
High-pressure liquid chromatography-ion-pair reversed-phase
High-pressure liquid chromatography—ion-pair reversed-phase, separation of penicillin and its major degradation products
Hydrogen-Ion Concentration
Penicillanic Acid - analysis
Penicillin G - analogs & derivatives
Penicillin-major degradation products
Penicillins - isolation & purification
Penicillin—major degradation products, separation by ion-pair reversed-phase high-pressure liquid chromatography
separation by ion-pair reversed-phase high-pressure liquid chromatography
separation of penicillin and its major degradation products
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Summary:An ion-pair reversed-phase high-pressure liquid chromatographic technique capable of separating penicillin and its major degradation products within 8 min was developed. The influence of pH, counterion concentration, buffer concentration, and organic modifier content was studied and the observed behavior of the compounds during the chromatographic process was discussed.
ISSN:0022-3549
1520-6017
DOI:10.1002/jps.2600710323