Ovarian development in 46,XY gonadal dysgenesis

In humans the XY ovary is degenerative, there being scant evidence of persistence of that organ beyond the perinatal period. Here we describe indications of functional ovarian tissue in a 17-year-old female with male karyotype, H-Y+ cellular phenotype, and some signs of the Turner syndrome. Her gona...

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Bibliographic Details
Published in:Human genetics 1982-01, Vol.60 (2), p.196-199
Main Authors: Russell, M H, Wachtel, S S, Davis, B W, Cahill, L T, Groos, E, Niblack, G D, Burr, I M
Format: Article
Language:English
Subjects:
Adolescent
Female
Gonadal Dysgenesis - pathology
Gonadal Dysgenesis, 46,XY - genetics
Gonadal Dysgenesis, 46,XY - pathology
H-Y Antigen - analysis
HLA Antigens - analysis
Humans
Lymphocytes - analysis
Ovary - pathology
Phenotype
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Summary:In humans the XY ovary is degenerative, there being scant evidence of persistence of that organ beyond the perinatal period. Here we describe indications of functional ovarian tissue in a 17-year-old female with male karyotype, H-Y+ cellular phenotype, and some signs of the Turner syndrome. Her gonads were removed after the onset of secondary amenorrhea. Histological examination revealed a degenerative right ovary devoid of germ cells and follicles, and a left streak gonad. There was no trace of testicular development in either side.
ISSN:0340-6717
1432-1203
DOI:10.1007/BF00569712